Excedrin and Ciprofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Ciprofloxacin (ciprofloxacin). Common drug interactions include blood glucose increased among females and abdominal abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Ciprofloxacin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Ciprofloxacin?

Ciprofloxacin has active ingredients of ciprofloxacin. It is often used in urinary tract infection. eHealthMe is studying from 22,256 Ciprofloxacin users. Check the latest studies of Ciprofloxacin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

25 people who take Excedrin and Ciprofloxacin together, and have interactions are studied.

Excedrin and Ciprofloxacin drug interactions.

What are the common drug interactions of Excedrin and Ciprofloxacin, by gender? *:

female:

Blood glucose increased
Chest discomfort
Chest pain
Chronic kidney disease
Erythema (redness of the skin)
Fungal infection
Muscle spasms (muscle contraction)
Skin cancer
Ligament sprain (ligament stretched)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

male:

Abdominal abscess (collection of pus in abdomen)
Abdominal pain upper
Hepatic steatosis (fatty liver disease)
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Nephrolithiasis (calculi in the kidneys)
Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)
Pleural effusion (water on the lungs)
Post procedural complication

What are the common drug interactions of Excedrin and Ciprofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chronic kidney disease
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis (infection of gallbladder)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Injury

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Jugular vein thrombosis (clot in jugular vein)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Transverse sinus thrombosis (a blood clot in transverse sinus)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

n/a

60+:

Blood glucose increased
Chest discomfort
Hepatic enzyme increased
Sinusitis (inflammation of sinus)
Neoplasm malignant (cancer tumour)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Decreased appetite
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hospitalisation

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 48.00%
Infection: 10 people, 40.00%
Pain: 10 people, 40.00%
Primary Immunodeficiency Syndrome: 6 people, 24.00%
Migraine (headache): 6 people, 24.00%
High Blood Cholesterol: 5 people, 20.00%
High Blood Pressure: 5 people, 20.00%
Inflammation: 3 people, 12.00%
Indigestion: 3 people, 12.00%
Rickets (softening of bones): 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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