Flexeril and Irbesartan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Irbesartan (irbesartan). Common drug interactions include device failure among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Irbesartan. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Irbesartan?

Irbesartan has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 36,414 Irbesartan users. Check the latest studies of Irbesartan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

57 people who take Flexeril and Irbesartan together, and have interactions are studied.

Flexeril and Irbesartan drug interactions.

What are the common drug interactions of Flexeril and Irbesartan, by gender? *:

female:

Device failure
Dizziness
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Fall
Gait disturbance
Hand fracture
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

male:

Asthenia (weakness)
Renal failure (kidney dysfunction)
Deafness
Depression
Diastolic dysfunction
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Gait disturbance
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Flexeril and Irbesartan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

40-49:

Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Dizziness
Fatigue (feeling of tiredness)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Diastolic dysfunction
Abdominal pain
Abdominal pain upper
Atelectasis (partial or complete collapse of the lung)

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Blood cholesterol increased
Blood glucose increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Gait disturbance
Henoch-schonlein purpura (inflammation of the blood vessels in the skin and other body organs)

60+:

Asthenia (weakness)
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Fall
Hand fracture
Loss of consciousness
Memory impairment
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

High Blood Cholesterol: 11 people, 19.30%
Pain: 10 people, 17.54%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.28%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.53%
Stress And Anxiety: 5 people, 8.77%
Blood Pressure Abnormal: 5 people, 8.77%
Depression: 5 people, 8.77%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 7.02%
Asthma: 4 people, 7.02%
Sleep Disorder: 4 people, 7.02%

* Approximation only. Some reports may have incomplete information.

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