Flurbiprofen and Indomethacin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Flurbiprofen (flurbiprofen) and Indomethacin (indomethacin). Common drug interactions include gastritis among females and hepatitis b among males.
The phase IV clinical study analyzes what interactions people have when they take Flurbiprofen and Indomethacin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.
What is Flurbiprofen?
Flurbiprofen has active ingredients of flurbiprofen. It is often used in rheumatoid arthritis. eHealthMe is studying from 2,677 Flurbiprofen users. Check the latest studies of Flurbiprofen.
What is Indomethacin?
Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 16,884 Indomethacin users. Check the latest studies of Indomethacin.
32 people who take Flurbiprofen and Indomethacin together, and have interactions are studied.

What are the common drug interactions of Flurbiprofen and Indomethacin, by gender? *:
female:
- Gastritis (inflammation of stomach)
- Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
- Gravitational oedema (abnormally large fluid volume in the circulatory system makes obese)
- Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)
- Hallucination, auditory (perceiving sounds without auditory stimulus)
- Hand fracture
- Hepatic steatosis (fatty liver disease)
- Hepatomegaly (abnormal enlargement of the liver)
- Hepatosplenomegaly (enlargement of both the liver and the spleen)
- Hot flush (sudden feelings of heat)
male:
- Hepatitis b
- Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
- Tachypnoea (a condition of rapid breathing over 20 per minute)
- Ventricular fibrillation (abnormally irregular heart rhythm)
- Cellulitis (infection under the skin)
- Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
- Febrile neutropenia (fever with reduced white blood cells)
- Fungal infection
- Renal failure (kidney dysfunction)
- Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
What are the common drug interactions of Flurbiprofen and Indomethacin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Cellulitis (infection under the skin)
- Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
- Febrile neutropenia (fever with reduced white blood cells)
- Fungal infection
- Renal failure (kidney dysfunction)
- Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
40-49:
- Drug hypersensitivity
50-59:
- Pyrexia (fever)
- Red blood cell count decreased
- Abdominal distension
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
- Ascites (accumulation of fluid in the abdominal cavity)
- Blood creatinine increased
- Blood urea increased
- Duodenal perforation (complication of duodenal ulcer)
- Duodenal ulcer
- Eye pain
60+:
- Arterial haemorrhage
- Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
- Drug hypersensitivity
- Acute circulatory failure (shock)
- Asthenia (weakness)
- Asthma
- Hyperpyrexia (extremely high fever)
- Hypertension (high blood pressure)
- Pneumonia
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
What are the existing conditions these people have? *
- Insomnia (sleeplessness): 3 people, 9.38%
- Adverse Drug Reaction: 3 people, 9.38%
- Tumor Invasion: 2 people, 6.25%
- Postrenal Failure (postrenal acute renal failure): 2 people, 6.25%
- Pancreatitis Acute (sudden inflammation of pancreas): 2 people, 6.25%
- Oedema Peripheral (superficial swelling): 2 people, 6.25%
- Nausea (feeling of having an urge to vomit): 2 people, 6.25%
- Myelosuppression (a decrease in the production of blood cells): 2 people, 6.25%
- Infusion Related Reaction: 2 people, 6.25%
- Fever: 2 people, 6.25%
* Approximation only. Some reports may have incomplete information.
Do you take Flurbiprofen and Indomethacin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Flurbiprofen (2,677 reports)
- Indomethacin (16,884 reports)
Browse all drug interactions of Flurbiprofen and Indomethacin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Flurbiprofen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Indomethacin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Flurbiprofen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Indomethacin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
- Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
- Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
- Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
How the study uses the data?
The study uses data from the FDA. It is based on flurbiprofen and indomethacin (the active ingredients of Flurbiprofen and Indomethacin, respectively), and Flurbiprofen and Indomethacin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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