Glucophage and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucophage (metformin hydrochloride) and Azelastine (azelastine hydrochloride). Common drug interactions include drug tolerance decreased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Glucophage and Azelastine. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

On Jul, 15, 2026

43 people who take Glucophage and Azelastine together, and have interactions are studied.

Glucophage and Azelastine drug interactions.

What are the common drug interactions of Glucophage and Azelastine, by gender? *:

female:

Drug tolerance decreased
Dry eye (lack of adequate tears)
Dyspepsia (indigestion)
Ear infection
Ear pain
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Genital infection
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)
Nephrogenic anaemia (anaemia due to kidney disease)
Anal abscess
Decreased appetite
Drug ineffective
Emotional distress
Genital abscess (build up of pus in genital)

What are the common drug interactions of Glucophage and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)
Anal abscess
Emotional distress
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cough
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dysarthria (speech disorder)
Fall
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Infusion site erythema (reddening of the skin at infusion site)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Acute respiratory failure
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Asthenia (weakness)
Confusional state

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 18.60%
Type 2 Diabetes: 7 people, 16.28%
Constipation: 7 people, 16.28%
High Blood Cholesterol: 7 people, 16.28%
Pain: 6 people, 13.95%
Asthma: 5 people, 11.63%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 11.63%
Depression: 5 people, 11.63%
Hypotension (abnormally low blood pressure): 4 people, 9.30%
Weight Decreased: 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

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