Glumetza and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glumetza (metformin hydrochloride) and Cymbalta (duloxetine hydrochloride). Common drug interactions include abdominal distension among females and limb injury among males.

The phase IV clinical study analyzes what interactions people have when they take Glumetza and Cymbalta. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Glumetza?

Glumetza has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,968 Glumetza users. Check the latest studies of Glumetza.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

On Jul, 03, 2026

79 people who take Glumetza and Cymbalta together, and have interactions are studied.

Glumetza and Cymbalta drug interactions.

What are the common drug interactions of Glumetza and Cymbalta, by gender? *:

female:

Abdominal distension
Abdominal pain
Anaphylactic reaction (serious allergic reaction)
Aspartate aminotransferase decreased
Asthenia (weakness)
Back pain
Blood creatinine decreased
Bradycardia (abnormally slow heart action)
Brain neoplasm (tumour of brain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Limb injury
Nausea (feeling of having an urge to vomit)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Nephrolithiasis (calculi in the kidneys)
Tendon injury
Urinary tract infection
Allergy to plants
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Glumetza and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain
Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Weight decreased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Restless legs syndrome (a powerful urge to move your legs)
Malaise (a feeling of general discomfort or uneasiness)
Mania (a state of abnormally elevated or irritable mood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pancreatitis (inflammation of pancreas)
Abdominal pain upper
Blood triglycerides increased
Cholecystitis (infection of gallbladder)

40-49:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Nephrolithiasis (calculi in the kidneys)
Tendon injury
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Libido decreased (loss of interest in sex)
Weight increased
Allergy to plants
Aspartate aminotransferase decreased

50-59:

Oedema (fluid collection in tissue)
Abdominal discomfort
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Urinary tract infection
Blood glucose decreased
Arthralgia (joint pain)

60+:

Drug ineffective
Arthralgia (joint pain)
Onycholysis (detachment of the nail from the nail bed)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Psoriasis (immune-mediated disease that affects the skin)
Genitourinary tract infection (infection of genital tract and urinary tract)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypokalaemia (low potassium)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 20.25%
Stress And Anxiety: 9 people, 11.39%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 11.39%
High Blood Cholesterol: 9 people, 11.39%
Type 2 Diabetes: 8 people, 10.13%
High Blood Pressure: 8 people, 10.13%
Hypersensitivity: 7 people, 8.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.86%
Insomnia (sleeplessness): 6 people, 7.59%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

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