Glyburide and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glyburide (glyburide) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include drug ineffective among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Glyburide and Prempro. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Glyburide?

Glyburide has active ingredients of glyburide. It is often used in diabetes. eHealthMe is studying from 38,448 Glyburide users. Check the latest studies of Glyburide.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Jul, 15, 2026

95 people who take Glyburide and Prempro together, and have interactions are studied.

Glyburide and Prempro drug interactions.

What are the common drug interactions of Glyburide and Prempro, by gender? *:

female:

Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Fall
Hypokalaemia (low potassium)
Mitral valve incompetence (inefficient heart valve)
Myalgia (muscle pain)
Pyrexia (fever)
Weight decreased
Arthralgia (joint pain)
Burning sensation

male:

Asthenia (weakness)
Breast cancer metastatic
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to lung (cancer spreads to lung)
Pneumonia
Anger
Anxiety

What are the common drug interactions of Glyburide and Prempro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Alcohol poisoning
Ammonia increased
Anaemia (lack of blood)
Arthropathy
Asthma
Back pain
Blood magnesium decreased
Breast cancer

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pyrexia (fever)
Weight increased
Anxiety
Irritability
Abscess neck (neck abscesses)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

60+:

Breast cancer female
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Oesophageal varices (extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Pruritus (severe itching of the skin)
Thrombocytopenia (decrease of platelets in blood)
Asthenia (weakness)
Blood glucose increased

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 12.63%
Type 2 Diabetes: 10 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 9.47%
High Blood Cholesterol: 8 people, 8.42%

* Approximation only. Some reports may have incomplete information.

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