Hctz and Cefazolin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hctz (hydrochlorothiazide) and Cefazolin (cefazolin sodium). Common drug interactions include ketoacidosis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hctz and Cefazolin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

What is Cefazolin?

Cefazolin has active ingredients of cefazolin sodium. It is often used in infection. eHealthMe is studying from 15,157 Cefazolin users. Check the latest studies of Cefazolin.

On Jul, 15, 2026

14 people who take Hctz and Cefazolin together, and have interactions are studied.

What are the common drug interactions of Hctz and Cefazolin, by gender? *:

female:

Ketoacidosis (high concentrations of ketone bodies in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Alopecia (absence of hair from areas of the body)
Chronic kidney disease
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Parkinson's disease
Psychological trauma
Renal failure (kidney dysfunction)

male:

Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to spine (cancer spreads to spine)
Peripheral swelling
Renal cell carcinoma (a kidney cancer)
Renal failure (kidney dysfunction)
Speech disorder
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the common drug interactions of Hctz and Cefazolin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Peripheral swelling
Speech disorder

50-59:

Renal failure (kidney dysfunction)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chronic kidney disease

60+:

Ketoacidosis (high concentrations of ketone bodies in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Alopecia (absence of hair from areas of the body)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to spine (cancer spreads to spine)
Parkinson's disease
Psychological trauma
Renal cell carcinoma (a kidney cancer)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
Constipation: 2 people, 14.29%
Type 2 Diabetes: 1 person, 7.14%
Blood Pressure Abnormal: 1 person, 7.14%
Breast Cancer Female: 1 person, 7.14%
Cardiac Failure: 1 person, 7.14%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 7.14%
Gastric Disorder (disease of stomach): 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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