Hycodan and Fosamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Fosamax (alendronate sodium). Common drug interactions include ascites among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Fosamax. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

On Jul, 12, 2026

19 people who take Hycodan and Fosamax together, and have interactions are studied.

What are the common drug interactions of Hycodan and Fosamax, by gender? *:

female:

Ascites (accumulation of fluid in the abdominal cavity)
Abdominal pain
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)
Headache (pain in head)
Hepatic haemorrhage (bleeding inside liver)

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Hycodan and Fosamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anaemia (lack of blood)
Abdominal pain
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Asthenia (weakness)
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disease progression

60+:

Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Idiopathic pulmonary fibrosis (chronic lung disease)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Uterine cancer

What are the existing conditions these people have? *

Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 8 people, 42.11%
High Blood Pressure: 6 people, 31.58%
Pain: 4 people, 21.05%
Nausea (feeling of having an urge to vomit): 4 people, 21.05%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 15.79%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 15.79%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 15.79%
Pain In Extremity: 3 people, 15.79%
Oedema (fluid collection in tissue): 2 people, 10.53%
Diarrhea: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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