Hyzaar and Prandin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hyzaar (hydrochlorothiazide; losartan potassium) and Prandin (repaglinide). Common drug interactions include dehydration among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Hyzaar and Prandin. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Prandin?

Prandin has active ingredients of repaglinide. It is often used in diabetes. eHealthMe is studying from 4,680 Prandin users. Check the latest studies of Prandin.

On Jul, 14, 2026

53 people who take Hyzaar and Prandin together, and have interactions are studied.

What are the common drug interactions of Hyzaar and Prandin, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Pitting oedema (skin discoloration)
Sedation
Throat tightness
Wheezing (a high-pitched whistling sound made while you breath)
Blood glucose decreased
Blood glucose increased
Neuropathy (damage to nerves)

male:

Cardiac failure congestive
Fatigue (feeling of tiredness)
Dizziness
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Feeling jittery
Hypoxia (low oxygen in tissues)
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Loss of consciousness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Hyzaar and Prandin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Visual disturbance
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Eye disorder
Glaucoma (increased fluid pressure in the eye with vision loss)
Malaise (a feeling of general discomfort or uneasiness)
Proteinuria present

50-59:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hyperlipidaemia (presence of excess lipids in the blood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancreatic carcinoma (pancreatic cancer)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin lesion

60+:

Cardiac failure congestive
Oedema peripheral (superficial swelling)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 16.98%
Type 2 Diabetes: 5 people, 9.43%
Oedema (fluid collection in tissue): 5 people, 9.43%
Stress And Anxiety: 3 people, 5.66%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 5.66%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 5.66%
Depression: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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