Ibuprofen and Ifosfamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ibuprofen (ibuprofen) and Ifosfamide (ifosfamide). Common drug interactions include osteoporosis among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Ibuprofen and Ifosfamide. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Ifosfamide?

Ifosfamide has active ingredients of ifosfamide. eHealthMe is studying from 21,285 Ifosfamide users. Check the latest studies of Ifosfamide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

58 people who take Ibuprofen and Ifosfamide together, and have interactions are studied.

Ibuprofen and Ifosfamide drug interactions.

What are the common drug interactions of Ibuprofen and Ifosfamide, by gender? *:

female:

Osteoporosis (bones weak and more likely to break)
Pyrexia (fever)
Upper limb fracture
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Neutropenic infection (infection with less neutrophil numbers in blood)
Anaemia (lack of blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Vomiting
Diarrhoea
Encephalopathy (functioning of the brain is affected by some agent or condition)

male:

Anaemia (lack of blood)
Cough
Fracture
Hip fracture
Multiple fractures
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pleuritic pain
Tooth loss

What are the common drug interactions of Ibuprofen and Ifosfamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Leukopenia (less number of white blood cells in blood)
Bone marrow failure
Constipation
Diarrhoea
Hypertension (high blood pressure)
Malignant neoplasm progression (cancer tumour came back)
Metastases to bone (cancer spreads to bone)
Myositis (inflammation of the muscles)
Nausea (feeling of having an urge to vomit)

10-19:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Pleuritic pain
Anaphylactic reaction (serious allergic reaction)
Cancer pain
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Constipation
Drug ineffective
Cough
Neutropenia (an abnormally low number of neutrophils)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

20-29:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Cough
Dyspepsia (indigestion)

30-39:

Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

40-49:

Acute circulatory failure (shock)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Bone density decreased
Depression
Emotional distress
Gastroenteritis (inflammation of stomach and intestine)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)
Interstitial lung disease

50-59:

Anaemia (lack of blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Diarrhoea
Pleural effusion (water on the lungs)
Vomiting
White blood cell count increased
Malignant melanoma (skin cancer rises from melancytes)
Second primary malignancy (after getting cure a cancer, a new cancer development)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Chest pain

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Neutropenic infection (infection with less neutrophil numbers in blood)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Tooth loss
Bacterial pericarditis (inflammation of the pericardial sac surrounding the heart due to bacterial infection)
Disease recurrence
Electrocardiogram qt prolonged
Escherichia infection (bacterial infection by escherichia coli)

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 16 people, 27.59%
Fever: 8 people, 13.79%
Diffuse Large B-Cell Lymphoma Stage Ii (cancer of b cells, a type of white blood cell-stage ii): 7 people, 12.07%
Constipation: 7 people, 12.07%
Osteosarcoma (a cancerous (malignant) bone tumour): 6 people, 10.34%
White Blood Cell Count Decreased: 5 people, 8.62%
Conjunctivitis (pink eye): 5 people, 8.62%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 5 people, 8.62%
Ph Urine Increased: 5 people, 8.62%
Nausea (feeling of having an urge to vomit): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

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