Imodium a-d and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium a-d (loperamide hydrochloride) and Naproxen (naproxen). Common drug interactions include abdominal pain lower among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium a-d and Naproxen. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 17, 2026

39 people who take Imodium a-d and Naproxen together, and have interactions are studied.

Imodium a-d and Naproxen drug interactions.

What are the common drug interactions of Imodium A-D and Naproxen, by gender? *:

female:

Abdominal pain lower
Abdominal pain upper
Activities of daily living impaired
Acute sinusitis
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood chloride decreased

male:

Abdominal discomfort
Abnormal dreams
Cerebral haemorrhage (bleeding within the brain)
Chronic kidney disease
Constipation
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Emotional distress

What are the common drug interactions of Imodium A-D and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hunger
Memory impairment
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

30-39:

n/a

40-49:

Chills (felling of cold)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Anaemia (lack of blood)
Blood triglycerides increased
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Laryngitis (inflammation of the larynx)
Loss of consciousness

50-59:

Influenza like illness
Muscular weakness (muscle weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug ineffective
Abdominal distension
Abdominal pain lower

60+:

Depression
Accidental exposure
Rectal haemorrhage (bleeding from anus)
Weight increased
Drug ineffective
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Asthma
Cardiac failure congestive

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 10.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.26%
Multiple Myeloma (cancer of the plasma cells): 4 people, 10.26%
Indigestion: 4 people, 10.26%
Thyroid Diseases: 3 people, 7.69%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 7.69%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 7.69%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 5.13%
Nausea And Vomiting: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium a-d and Naproxen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously