Insulin and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Insulin (insulin pork) and Xgeva (denosumab). Common drug interactions include hypertension among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Insulin and Xgeva. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Insulin?

Insulin has active ingredients of insulin pork. It is often used in diabetes. eHealthMe is studying from 50,203 Insulin users. Check the latest studies of Insulin.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

On Jul, 12, 2026

76 people who take Insulin and Xgeva together, and have interactions are studied.

What are the common drug interactions of Insulin and Xgeva, by gender? *:

female:

Hypertension (high blood pressure)
Intervertebral disc degeneration (spinal disc degeneration)
Lumbar radiculopathy (radicular pain in the low back and legs)
Lymphangiectasia intestinal (a disease of the lymphatic vessels of intestine that results in the leakage of protein-rich lymph)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Pulmonary mass
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Skin ulcer
Varicose vein (veins that have become enlarged and tortuous)

male:

Fatigue (feeling of tiredness)
Fall
Decreased appetite
General physical health deterioration (weak health status)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Abasia (inability to walk)
Anaemia (lack of blood)
Back pain
Cancer pain
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

What are the common drug interactions of Insulin and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Osteonecrosis of jaw (death of bone of jaw)
Abscess (pus)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Colostomy
Diabetes mellitus inadequate control
Dyspnoea (difficult or laboured respiration)
Feeling hot
Fistula (an abnormal connection or passageway between two)

50-59:

Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Oral pain
Purulent discharge (discharge that contains pus)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Renal failure (kidney dysfunction)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Asthenia (weakness)

60+:

Fatigue (feeling of tiredness)
Osteonecrosis of jaw (death of bone of jaw)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Dehydration (dryness resulting from the removal of water)
Weight decreased
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Abasia (inability to walk)
Arthralgia (joint pain)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 23.68%
Metastases To Bone (cancer spreads to bone): 17 people, 22.37%
Prostate Cancer: 12 people, 15.79%
Breast Cancer Metastatic: 12 people, 15.79%
Prostate Cancer Metastatic: 9 people, 11.84%
Hyperglycemia (high blood sugar): 8 people, 10.53%
Anaemia (lack of blood): 7 people, 9.21%
Stress And Anxiety: 7 people, 9.21%
Bone Pain: 7 people, 9.21%
Insomnia (sleeplessness): 6 people, 7.89%

* Approximation only. Some reports may have incomplete information.

Do you take Insulin and Xgeva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously