Keppra and Rabeprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra (levetiracetam) and Rabeprazole (rabeprazole sodium). Common drug interactions include amnesia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra and Rabeprazole. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Rabeprazole?

Rabeprazole has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 31,689 Rabeprazole users. Check the latest studies of Rabeprazole.

On Jul, 09, 2026

87 people who take Keppra and Rabeprazole together, and have interactions are studied.

Keppra and Rabeprazole drug interactions.

What are the common drug interactions of Keppra and Rabeprazole, by gender? *:

female:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Dysarthria (speech disorder)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Encephalopathy (functioning of the brain is affected by some agent or condition)

male:

Pyrexia (fever)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Hemiparesis (weakness on one side of the body)
Hypotension (abnormally low blood pressure)
Overdose
Platelet count decreased
Weight increased
Blood pressure diastolic increased
Blood pressure increased
Body temperature decreased

What are the common drug interactions of Keppra and Rabeprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Coagulopathy (blood's ability to clot is impaired)
Hyperchloraemia (an excess of chlorides in the blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypoproteinaemia (too little prolactin circulating in the blood)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Pneumonia

10-19:

Diarrhoea
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Pneumonia

20-29:

Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Bronchial obstruction (blockage of the breathing passages to the lungs)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Laryngeal oedema (swelling of larynx)
Liver disorder (liver diseases)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)

30-39:

Back pain
Central nervous system necrosis (destruction of central nervous system)
Chronic kidney disease
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disease progression
Dyspnoea (difficult or laboured respiration)
Lung disorder (lung disease)
Melaena (the passage of black, tarry stools)
Mouth haemorrhage (bleeding from mouth)

40-49:

Blood pressure diastolic increased
Blood pressure increased
Body temperature decreased
Bone marrow disorder
Bone marrow failure
Confusional state
Dyspepsia (indigestion)
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhage (bleeding)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disease progression
Drug administration error
Drug ineffective
Dry throat
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Gamma-glutamyltransferase increased
Hypertension (high blood pressure)
Ill-defined disorder

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Urinary tract infection
Death
Febrile neutropenia (fever with reduced white blood cells)
Platelet count decreased
Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
Pneumonia
Anaemia (lack of blood)
Depressed level of consciousness

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 16.09%
Lung Cancer - Non-Small Cell (lung cancer): 9 people, 10.34%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 9.20%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 8 people, 9.20%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 7 people, 8.05%
Dyslipidaemia (abnormal amount of lipids): 7 people, 8.05%
Pain: 6 people, 6.90%
Depression: 6 people, 6.90%
Osteoporosis (bones weak and more likely to break): 5 people, 5.75%
Lung Cancer - Small Cell (lung cancer): 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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