L-methylfolate and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take L-methylfolate (folic acid) and Wellbutrin (bupropion hydrochloride). Common drug interactions include fatigue among females and abnormal dreams among males.

The phase IV clinical study analyzes what interactions people have when they take L-methylfolate and Wellbutrin. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is L-methylfolate?

L-methylfolate has active ingredients of folic acid. It is often used in depression. eHealthMe is studying from 619 L-methylfolate users. Check the latest studies of L-methylfolate.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,115 Wellbutrin users. Check the latest studies of Wellbutrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

47 people who take L-methylfolate and Wellbutrin together, and have interactions are studied.

L-methylfolate and Wellbutrin drug interactions.

What are the common drug interactions of L-Methylfolate and Wellbutrin, by gender? *:

female:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Headache (pain in head)
Drug ineffective
Apnoea (suspension of external breathing)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematoma (collection of blood outside the blood vessels)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)

male:

Abnormal dreams
Blood prolactin increased
Weight decreased
Breast enlargement
Drug effect decreased
Hallucination, auditory (perceiving sounds without auditory stimulus)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nasopharyngitis (inflammation of the nasopharynx)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of L-Methylfolate and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Muscular weakness (muscle weakness)

30-39:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Inflammatory bowel disease
Abnormal dreams
Dry mouth
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Bipolar disorder (mood disorder)
Brain injury
Cerebral disorder (brain disease)
Chest discomfort
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Drug ineffective

50-59:

Drug ineffective
Tardive dyskinesia (a disorder that involves involuntary movements)
Dysuria (painful or difficult urination)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Memory impairment
Muscle spasms (muscle contraction)
Night sweats (sweating in night)
Respiratory tract infection
Sleep disorder

60+:

Asthenia (weakness)
Contusion (a type of hematoma of tissue in which capillaries)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Glomerular filtration rate decreased
Herpes zoster
Ill-defined disorder
Injection site pruritus (severe itching at injection site)
Pain
Rash
Rash erythematous (redness of the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 27.66%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 19.15%
Stress And Anxiety: 5 people, 10.64%
Immunodeficiency Common Variable: 5 people, 10.64%
Insomnia (sleeplessness): 3 people, 6.38%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.38%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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