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Lamotrigine and Paraflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Paraflex (chlorzoxazone). Common drug interactions include intentional self-injury among females.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Paraflex. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Paraflex?

Paraflex has active ingredients of chlorzoxazone. eHealthMe is studying from 242 Paraflex users. Check the latest studies of Paraflex.

On Jul, 19, 2026

19 people who take Lamotrigine and Paraflex together, and have interactions are studied.

Lamotrigine and Paraflex drug interactions.

What are the common drug interactions of Lamotrigine and Paraflex, by gender? *:

female:

  1. Intentional self-injury
  2. Fatigue (feeling of tiredness)
  3. Suicide attempt
  4. Alanine aminotransferase increased
  5. Poisoning
  6. Depressed level of consciousness
  7. Hypertension (high blood pressure)
  8. Analgesic drug level increased
  9. Aspartate aminotransferase increased
  10. Blood lactate dehydrogenase increased

male:

n/a

What are the common drug interactions of Lamotrigine and Paraflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Overdose
  2. Suicide attempt
  3. Alanine aminotransferase increased
  4. Poisoning
  5. Fatigue (feeling of tiredness)
  6. Hypertension (high blood pressure)
  7. Intentional self-injury
  8. Analgesic drug level increased
  9. Aspartate aminotransferase increased
  10. Blood lactate dehydrogenase increased

30-39:

n/a

40-49:

  1. Fatigue (feeling of tiredness)
  2. Intentional self-injury

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Suicide Attempt: 1 person, 5.26%
  2. Pain: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and Paraflex?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lamotrigine and Paraflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Paraflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lamotrigine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paraflex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine and chlorzoxazone (the active ingredients of Lamotrigine and Paraflex, respectively), and Lamotrigine and Paraflex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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