Lansoprazole and Epclusa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lansoprazole (lansoprazole) and Epclusa (sofosbuvir; velpatasvir). Common drug interactions include atrial fibrillation among females and hepatic encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Lansoprazole and Epclusa. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Lansoprazole?

Lansoprazole has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 129,663 Lansoprazole users. Check the latest studies of Lansoprazole.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

On Jul, 27, 2026

17 people who take Lansoprazole and Epclusa together, and have interactions are studied.

Lansoprazole and Epclusa drug interactions.

What are the common drug interactions of Lansoprazole and Epclusa, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hepatic failure (liver failure)
Bradycardia (abnormally slow heart action)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Blood potassium increased
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Varicose vein (veins that have become enlarged and tortuous)

male:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Dysuria (painful or difficult urination)
Emotional distress
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)
Osteonecrosis (death of bone)
Pain
Renal failure (kidney dysfunction)
Tooth loss

What are the common drug interactions of Lansoprazole and Epclusa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hepatic failure (liver failure)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Chronic kidney disease
Dysuria (painful or difficult urination)
Emotional distress
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Renal impairment (severely reduced kidney function)
Hepatic failure (liver failure)
Ascites (accumulation of fluid in the abdominal cavity)
Bradycardia (abnormally slow heart action)
Cerebellar haemorrhage (bleeding in cerebeller)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Dyspnoea (difficult or laboured respiration)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

What are the existing conditions these people have? *

Hepatitis C: 11 people, 64.71%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 9 people, 52.94%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.76%
Hiv Infection: 2 people, 11.76%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 2 people, 11.76%
Hepatic Function Abnormal: 1 person, 5.88%
Cardiac Failure: 1 person, 5.88%
Diabetes: 1 person, 5.88%
Gastric Ulcer (stomach ulcer): 1 person, 5.88%
Gastritis - Chronic (long lasting inflammation of stomach): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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