Lansoprazole and Purinethol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lansoprazole (lansoprazole) and Purinethol (mercaptopurine). Common drug interactions include anal fissure among females and cholestasis among males.

The phase IV clinical study analyzes what interactions people have when they take Lansoprazole and Purinethol. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Lansoprazole?

Lansoprazole has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 129,663 Lansoprazole users. Check the latest studies of Lansoprazole.

What is Purinethol?

Purinethol has active ingredients of mercaptopurine. It is often used in ulcerative colitis. eHealthMe is studying from 3,810 Purinethol users. Check the latest studies of Purinethol.

On Aug, 05, 2026

18 people who take Lansoprazole and Purinethol together, and have interactions are studied.

Lansoprazole and Purinethol drug interactions.

What are the common drug interactions of Lansoprazole and Purinethol, by gender? *:

female:

Anal fissure
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Haematochezia (passage of stools containing blood)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Proctalgia (pain in the rectum)
Productive cough
Psoriasis (immune-mediated disease that affects the skin)
Arthralgia (joint pain)
Asthenia (weakness)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

male:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatomegaly (abnormal enlargement of the liver)
Weight increased
Hepatocellular injury (liver injury)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Overdose
Abdominal distension
Drug ineffective
Hepatitis acute

What are the common drug interactions of Lansoprazole and Purinethol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatomegaly (abnormal enlargement of the liver)
Anal fissure
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Haematochezia (passage of stools containing blood)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Proctalgia (pain in the rectum)
Productive cough

20-29:

n/a

30-39:

Abdominal distension
Arthralgia (joint pain)
Asthenia (weakness)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Diarrhoea haemorrhagic (bloody diarrhoea)
Diplopia (double vision)
Disturbance in attention
Encephalitis (inflammation of the brain)
Eye disorder
Fatigue (feeling of tiredness)

40-49:

n/a

50-59:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatocellular injury (liver injury)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Overdose
Spinal cord injury

60+:

Psoriasis (immune-mediated disease that affects the skin)
Septic shock (shock due to blood infection)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 27.78%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 22.22%
Respiratory Tract Infection: 3 people, 16.67%
Joint Pain: 3 people, 16.67%
Infection: 2 people, 11.11%
Fungal Infection: 2 people, 11.11%
Herpes Virus Infection: 1 person, 5.56%
Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 1 person, 5.56%
Depression: 1 person, 5.56%
Constipation: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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