Leucovorin calcium and Novolog drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leucovorin calcium (leucovorin calcium) and Novolog (insulin aspart recombinant). Common drug interactions include haemorrhagic anaemia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Leucovorin calcium and Novolog. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Leucovorin calcium?

Leucovorin calcium has active ingredients of leucovorin calcium. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,650 Leucovorin calcium users. Check the latest studies of Leucovorin calcium.

What is Novolog?

Novolog has active ingredients of insulin aspart recombinant. It is often used in diabetes. eHealthMe is studying from 56,160 Novolog users. Check the latest studies of Novolog.

On Jul, 09, 2026

32 people who take Leucovorin calcium and Novolog together, and have interactions are studied.

Leucovorin calcium and Novolog drug interactions.

What are the common drug interactions of Leucovorin Calcium and Novolog, by gender? *:

female:

Haemorrhagic anaemia (anaemia due to excessive bleeding)
Heart rate increased
Hypokalaemia (low potassium)
Infection
Melaena (the passage of black, tarry stools)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple injuries
Rash
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)

male:

Diarrhoea
Pyrexia (fever)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood bicarbonate decreased
Blood chloride increased
Blood creatinine increased
Blood phosphorus decreased
Chills (felling of cold)
Confusional state

What are the common drug interactions of Leucovorin Calcium and Novolog, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure increased
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Eye pain
Fall
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Infusion site infection
Localised infection (infection at the single location)
Oral candidiasis (fungal infection of mouth)

50-59:

Colorectal cancer (colon cancer or bowel cancer)
Drug effect decreased
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urinary incontinence (inability to control the flow of urine and involuntary urination)

60+:

Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bradycardia (abnormally slow heart action)
Chest discomfort
Dehydration (dryness resulting from the removal of water)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematocrit decreased
Haemoglobin decreased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 18.75%
Colon Cancer: 6 people, 18.75%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 4 people, 12.50%
Cardiac Failure Congestive: 3 people, 9.38%
Rectal Cancer (cancer of rectum): 2 people, 6.25%
Neoplasm Malignant (cancer tumour): 2 people, 6.25%
Hypersensitivity: 2 people, 6.25%
High Blood Cholesterol: 2 people, 6.25%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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