Lodine and Cipro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lodine (etodolac) and Cipro (ciprofloxacin hydrochloride). Common drug interactions include arthralgia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lodine and Cipro. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.



On Jul, 12, 2026

70 people who take Lodine and Cipro together, and have interactions are studied.

Lodine and Cipro drug interactions.

What are the common drug interactions of Lodine and Cipro, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  3. Constipation
  4. Myalgia (muscle pain)
  5. Anxiety
  6. Asthenia (weakness)
  7. Device related infection
  8. Diarrhoea
  9. General physical health deterioration (weak health status)
  10. Osteonecrosis of jaw (death of bone of jaw)

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Dizziness
  3. Irritability
  4. Suicidal ideation
  5. Back pain
  6. Nausea (feeling of having an urge to vomit)
  7. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  8. Weight decreased
  9. Asthenia (weakness)
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Lodine and Cipro, by age (0-1 to 60+)? *:

0-1:

  1. Pulmonary artery stenosis congenital (congenital -narrowing (stenosis) that occurs in the lung artery)

2-9:

n/a

10-19:

n/a

20-29:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Hypokalaemia (low potassium)
  3. Pain in extremity
  4. Abdominal discomfort
  5. Abdominal pain
  6. Abdominal pain upper
  7. Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
  8. Cholecystitis chronic (long lasting infection of gallbladder)
  9. Cholesterosis (abnormal deposition of cholesterol in tissues)
  10. Diarrhoea

30-39:

  1. Back pain
  2. Depression
  3. Irritability
  4. Drug dependence
  5. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  7. Nausea (feeling of having an urge to vomit)
  8. Abnormal dreams
  9. Arthralgia (joint pain)
  10. Chest pain

40-49:

  1. Dyskinesia (abnormality or impairment of voluntary movement)
  2. Anxiety
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Depression
  5. Alopecia (absence of hair from areas of the body)
  6. Aortic arteriosclerosis (hardening of the aortic arteries)
  7. Arthralgia (joint pain)
  8. Asthenia (weakness)
  9. Back pain
  10. Blood glucose decreased

50-59:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Asthenia (weakness)
  3. Atrophic vulvovaginitis (inflammation of the vulva)
  4. Back disorder
  5. Benign neoplasm of adrenal gland (benign (non-cancerous) tumours of the adrenal gland)
  6. Blindness
  7. Bone disorder
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Bruxism (habitual grinding of the teeth, typically during sleep)
  10. Cataract (clouding of the lens inside the eye)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Swelling
  4. Abdominal pain upper
  5. Anaemia (lack of blood)
  6. Anxiety
  7. Aortic arteriosclerosis (hardening of the aortic arteries)
  8. Aortic dilatation
  9. Asthenia (weakness)
  10. Bone disorder

What are the existing conditions these people have? *

  1. Stress And Anxiety: 23 people, 32.86%
  2. Nausea (feeling of having an urge to vomit): 6 people, 8.57%
  3. Multiple Myeloma (cancer of the plasma cells): 6 people, 8.57%
  4. Asthma: 6 people, 8.57%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.71%
  6. Constipation: 4 people, 5.71%
  7. Anaemia (lack of blood): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lodine and Cipro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lodine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cipro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lodine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cipro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on etodolac and ciprofloxacin hydrochloride (the active ingredients of Lodine and Cipro, respectively), and Lodine and Cipro (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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