Lonsurf and Vectibix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Vectibix (panitumumab). Common drug interactions include blood culture positive among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Vectibix. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Vectibix?

Vectibix has active ingredients of panitumumab. eHealthMe is studying from 8,945 Vectibix users. Check the latest studies of Vectibix.

On Jul, 27, 2026

50 people who take Lonsurf and Vectibix together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Vectibix, by gender? *:

female:

Blood culture positive
Blood magnesium decreased
Diarrhoea
Fatigue (feeling of tiredness)
Feeling cold
Sneezing
Death
Abdominal pain
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Death
Rash
Tracheal stenosis (narrowing of trachea)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Alopecia (absence of hair from areas of the body)
Constipation
Haemoglobin decreased
Rectal cancer (cancer of rectum)
Red blood cell count decreased
Skin disorder (skin disease)

What are the common drug interactions of Lonsurf and Vectibix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angiopathy (generic term for a disease of the blood vessels)
Disease progression
Haematoma (collection of blood outside the blood vessels)
Proctitis haemorrhagic (inflammation of the rectum and anus)

30-39:

n/a

40-49:

Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Anaemia (lack of blood)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Xeroderma (dry skin include itching and red, cracked or flaky skin)
Acute respiratory failure
Dyspnoea (difficult or laboured respiration)
Neck pain
Post procedural complication

50-59:

Death
Hypersensitivity
Rash
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Rectal cancer (cancer of rectum)
Somnolence (a state of near-sleep, a strong desire for sleep)
Disease progression
Metastases to lung (cancer spreads to lung)
Neoplasm progression (growth of tumour)
Acne (skin problems that cause pimples)

60+:

Haemoglobin decreased
Neutropenia (an abnormally low number of neutrophils)
Blood magnesium decreased
Decreased appetite
Feeling cold
Platelet count decreased
Sneezing
Death
Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 27 people, 54.00%
Colon Cancer: 13 people, 26.00%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 7 people, 14.00%
Rectal Cancer (cancer of rectum): 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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