Lupron and Creon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron (leuprolide acetate) and Creon (pancrelipase (amylase;lipase;protease)). Common drug interactions include cellulitis among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron and Creon. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

27 people who take Lupron and Creon together, and have interactions are studied.

What are the common drug interactions of Lupron and Creon, by gender? *:

female:

Cellulitis (infection under the skin)
Folliculitis (infection of hair root)
Pyrexia (fever)
Rash papular (redness with papule)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Hot flush (sudden feelings of heat)
Vaginal haemorrhage (vaginal bleeding)
Cataract (clouding of the lens inside the eye)
Anxiety

male:

Death
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug hypersensitivity
Gait disturbance
Hemiparesis (weakness on one side of the body)
Impaired work ability
Muscle atrophy (a decrease in the mass of the muscle)
Precancerous cells present
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Lupron and Creon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hepatic enzyme increased

10-19:

n/a

20-29:

Anxiety
Back pain
Headache (pain in head)
Hot flush (sudden feelings of heat)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Mood swings (an extreme or rapid change in mood)
Muscle spasms (muscle contraction)
Pain
Vaginal haemorrhage (vaginal bleeding)

30-39:

Abdominal pain
Abscess (pus)
Blood oestrogen decreased
Chest discomfort
Constipation
Dysphagia (a condition in which swallowing is difficult or painful)
Frequent bowel movements
Haemoglobin decreased
Hypertension (high blood pressure)
Injection site cyst

40-49:

Post procedural infection
Thyroid cancer

50-59:

Cellulitis (infection under the skin)
Folliculitis (infection of hair root)
Pyrexia (fever)
Rash papular (redness with papule)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Cataract (clouding of the lens inside the eye)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Blood pressure decreased
Death

60+:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Muscle atrophy (a decrease in the mass of the muscle)
Pneumonia
Precancerous cells present
Prostatic specific antigen increased
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight decreased
Weight increased
Abasia (inability to walk)

What are the existing conditions these people have? *

Prostate Cancer: 9 people, 33.33%
Pain: 8 people, 29.63%
Hypersensitivity: 7 people, 25.93%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 18.52%
Rashes (redness): 5 people, 18.52%
Indigestion: 5 people, 18.52%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 18.52%
Cystic Fibrosis (disease of the secretary glands): 4 people, 14.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%
Acne (skin problems that cause pimples): 3 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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