Lupron and Robaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron (leuprolide acetate) and Robaxin (methocarbamol). Common drug interactions include abdominal hernia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron and Robaxin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Robaxin?

Robaxin has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 9,109 Robaxin users. Check the latest studies of Robaxin.

On Aug, 10, 2026

32 people who take Lupron and Robaxin together, and have interactions are studied.

What are the common drug interactions of Lupron and Robaxin, by gender? *:

female:

Abdominal hernia
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Compression fracture (fracture due to pressure caused by injury)
Depression
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
General physical health deterioration (weak health status)
Injury
Iron deficiency anaemia
Joint injury
Metastases to spine (cancer spreads to spine)

male:

Diarrhoea
Fatigue (feeling of tiredness)
Rash
Rhinorrhoea (watery mucus discharge from the nose)
Visual impairment
Constipation
Vertigo
Abdominal discomfort
Abdominal distension
Anaemia (lack of blood)

What are the common drug interactions of Lupron and Robaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Anxiety
Arthralgia (joint pain)
Chest pain
Chills (felling of cold)
Complication of device insertion
Hot flush (sudden feelings of heat)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Abdominal adhesions (inflammation of abdomen)
Arthralgia (joint pain)
Intestinal perforation (complete penetration of the wall of the intestine)
Localised infection (infection at the single location)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

40-49:

Tooth loss
Abdominal distension
Arthralgia (joint pain)
Bone pain
Dyspepsia (indigestion)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperlipidaemia (presence of excess lipids in the blood)
Memory impairment
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug effect increased
Drug hypersensitivity
Endotracheal intubation complication
Femur fracture
Abdominal hernia
Anaemia (lack of blood)

60+:

Constipation
Cough
Neuropathy peripheral (surface nerve damage)
Prostatic specific antigen increased
Rash
Rhinorrhoea (watery mucus discharge from the nose)
Sinus disorder (disease of sinus)
Vertigo
Visual impairment
Diarrhoea

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 20 people, 62.50%
Prostate Cancer: 8 people, 25.00%
Metastases To Bone Marrow (cancer spreads to bone marrow): 4 people, 12.50%
Pain: 3 people, 9.38%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 6.25%
Osteoporosis (bones weak and more likely to break): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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