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Menest and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Menest (estrogens, esterified) and Metformin (metformin hydrochloride). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Menest and Metformin. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Menest?

Menest has active ingredients of estrogens, esterified. It is often used in hormone replacement therapy. eHealthMe is studying from 843 Menest users. Check the latest studies of Menest.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 16, 2026

23 people who take Menest and Metformin together, and have interactions are studied.

Menest and Metformin drug interactions.

What are the common drug interactions of Menest and Metformin, by gender? *:

female:

  1. Drug ineffective
  2. Diarrhoea
  3. Blood glucose increased
  4. Chronic kidney disease
  5. Cough
  6. Drug intolerance (drug sensitivity)
  7. Dyspnoea (difficult or laboured respiration)
  8. Food allergy
  9. Hyperglycaemia (high blood sugar)
  10. Hypersensitivity

male:

n/a

What are the common drug interactions of Menest and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Back pain
  2. Drug ineffective
  3. Pain in extremity

20-29:

n/a

30-39:

  1. Adverse event
  2. Angioedema (rapid swelling of the dermis)
  3. Blood glucose increased
  4. Dyspnoea (difficult or laboured respiration)
  5. Food allergy
  6. Hypercholesterolaemia (high levels of cholesterol in the blood)
  7. Hyperglycaemia (high blood sugar)
  8. Hypersensitivity
  9. Increased appetite
  10. Irritability

40-49:

n/a

50-59:

n/a

60+:

  1. Drug ineffective
  2. Constipation
  3. Infection
  4. Lipase increased
  5. Renal failure (kidney dysfunction)
  6. Renal injury (kidney injury)
  7. Upper respiratory tract infection
  8. Weight decreased
  9. Arthralgia (joint pain)
  10. Arthropathy

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 7 people, 30.43%
  2. Psoriasis (immune-mediated disease that affects the skin): 5 people, 21.74%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 17.39%
  4. Pain: 3 people, 13.04%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
  6. Immunodeficiency Common Variable: 2 people, 8.70%
  7. High Blood Cholesterol: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Menest and Metformin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Menest and Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Menest:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Menest and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, esterified and metformin hydrochloride (the active ingredients of Menest and Metformin, respectively), and Menest and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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