Methotrexate and Akineton drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Akineton (biperiden hydrochloride). Common drug interactions include decreased appetite among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Akineton. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

On Jul, 28, 2026

12 people who take Methotrexate and Akineton together, and have interactions are studied.

Methotrexate and Akineton drug interactions.

What are the common drug interactions of Methotrexate and Akineton, by gender? *:

female:

Decreased appetite
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Folliculitis (infection of hair root)
Herpes zoster
Hypertension (high blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Infected dermal cyst
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Platelet count decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal failure acute (rapid kidney dysfunction)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Drug level increased
Drug toxicity
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)

What are the common drug interactions of Methotrexate and Akineton, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal failure acute (rapid kidney dysfunction)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Drug level increased
Drug toxicity
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)

20-29:

n/a

30-39:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Cardiotoxicity (damage to the heart muscle)
Chest pain
Troponin increased

40-49:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

50-59:

n/a

60+:

Altered state of consciousness (altered state of mind)
Aspergillosis oral
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Platelet count decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Stupor (lack of critical cognitive function and level of consciousness)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal discomfort
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Leukopenia (less number of white blood cells in blood)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 25.00%
Stress And Anxiety: 2 people, 16.67%
Depression: 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%
Psychiatric Symptom: 1 person, 8.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 8.33%
Acute Psychosis (period of mentally unstable behaviour): 1 person, 8.33%
Agitation (state of anxiety or nervous excitement): 1 person, 8.33%
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 1 person, 8.33%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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