Methylin and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylin (methylphenidate hydrochloride) and Simvastatin (simvastatin). Common drug interactions include osteoarthritis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Methylin and Simvastatin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Methylin?

Methylin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,116 Methylin users. Check the latest studies of Methylin.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

On Aug, 07, 2026

56 people who take Methylin and Simvastatin together, and have interactions are studied.

Methylin and Simvastatin drug interactions.

What are the common drug interactions of Methylin and Simvastatin, by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Radiation injury (injuries are caused by radiation)
Sinus disorder (disease of sinus)
Sinusitis fungal (fungal infection of sinus)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Joint dislocation (a joint position is changed from normal position)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Cerumen impaction

male:

Chronic kidney disease
Renal injury (kidney injury)
Anxiety
Crying
Decreased appetite
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hostility

What are the common drug interactions of Methylin and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Loss of consciousness

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Depressed mood
Diarrhoea
Disturbance in attention
Dysphagia (a condition in which swallowing is difficult or painful)
Fear
Hypokalaemia (low potassium)
Joint dislocation (a joint position is changed from normal position)
Sleep disorder
Small intestinal obstruction (blockage in small intestine)
Stress

60+:

Depression
Fall
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)
Back pain
Brain neoplasm (tumour of brain)
Breast cancer metastatic
Carotid bruit (sound heard over the carotid artery area during auscultation)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

What are the existing conditions these people have? *

Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 16 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.93%
Drowsiness: 5 people, 8.93%
Pain: 4 people, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.14%
High Blood Pressure: 4 people, 7.14%
Depression: 4 people, 7.14%
Insomnia (sleeplessness): 3 people, 5.36%
Gout (uric acid crystals building up in the body): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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