Moduretic 5-50 and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Moduretic 5-50 (amiloride hydrochloride; hydrochlorothiazide) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include international normalised ratio increased among females and dermatitis bullous among males.

The phase IV clinical study analyzes what interactions people have when they take Moduretic 5-50 and Isosorbide dinitrate. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Moduretic 5-50?

Moduretic 5-50 has active ingredients of amiloride hydrochloride; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 3,224 Moduretic 5-50 users. Check the latest studies of Moduretic 5-50.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 10, 2026

13 people who take Moduretic 5-50 and Isosorbide dinitrate together, and have interactions are studied.

Moduretic 5-50 and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Moduretic 5-50 and Isosorbide Dinitrate, by gender? *:

female:

International normalised ratio increased
Rib fracture
Hyperkalaemia (damage to or disease of the kidney)
Blood antidiuretic hormone increased
Blood osmolarity increased
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Fatigue (feeling of tiredness)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypokalaemia (low potassium)

male:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Acute abdomen
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pemphigoid (tense blisters on the skin)
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters)
Pruritus (severe itching of the skin)
Rash pruritic (redness with itching)

What are the common drug interactions of Moduretic 5-50 and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hyperkalaemia (damage to or disease of the kidney)

60+:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotonia (low muscle tone)
Inappropriate adh secretion

What are the existing conditions these people have? *

Diabetes: 5 people, 38.46%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 15.38%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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