Mucinex d and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex d (guaifenesin; pseudoephedrine hydrochloride) and Naproxen (naproxen). Common drug interactions include vomiting among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex d and Naproxen. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex d?

Mucinex d has active ingredients of guaifenesin; pseudoephedrine hydrochloride. It is often used in sinus congestion. eHealthMe is studying from 1,926 Mucinex d users. Check the latest studies of Mucinex d.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 09, 2026

25 people who take Mucinex d and Naproxen together, and have interactions are studied.

Mucinex d and Naproxen drug interactions.

What are the common drug interactions of Mucinex D and Naproxen, by gender? *:

female:

Vomiting
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Respiratory tract congestion (blockage on respiratory system)
Therapeutic response unexpected
Arthropathy
Back disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Migraine (headache)
Fatigue (feeling of tiredness)

male:

Constipation
Dizziness
Chronic kidney disease
Depression
Dyspnoea (difficult or laboured respiration)
Emotional distress
Headache (pain in head)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Mucinex D and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Respiratory tract congestion (blockage on respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)

20-29:

n/a

30-39:

Tendonitis (a condition that causes pain and swelling of tendons)
Tremor (trembling or shaking movements in one or more parts of your body)
Tricuspid valve incompetence (inefficient heart valve)
Urticaria chronic (long lasting rash of round, red welts on the skin that itch intensely)
Vertigo
Weight decreased
Abdominal discomfort
Abnormal behaviour
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Alanine aminotransferase increased

40-49:

Depression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Insomnia (sleeplessness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Neuralgia (pain in one or more nerves)
Pain in extremity

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Depression
Drug ineffective
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Injection site bruising
Injection site discolouration
Injection site erythema (redness at injection site)

60+:

Body height decreased
Memory impairment
Periportal oedema (swelling from excessive accumulation of watery fluid in periportal)
Therapeutic response unexpected
Urinary retention (the inability to completely or partially empty the bladder)
Viral infection
Vomiting
Spinal pain (pain in spine)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Visual acuity reduced (reduced clearness of vision)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 56.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 44.00%
Hypersensitivity: 5 people, 20.00%
Diabetes: 4 people, 16.00%
Drowsiness: 3 people, 12.00%
Blood Pressure Abnormal: 3 people, 12.00%
Breast Cancer Female: 3 people, 12.00%
Asthma: 3 people, 12.00%
Insomnia (sleeplessness): 3 people, 12.00%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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