Naproxen and Covera-hs drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Covera-hs (verapamil hydrochloride). Common drug interactions include fall among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Covera-hs. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Covera-hs?

Covera-hs has active ingredients of verapamil hydrochloride. eHealthMe is studying from 823 Covera-hs users. Check the latest studies of Covera-hs.



On Jul, 19, 2026

22 people who take Naproxen and Covera-hs together, and have interactions are studied.

Naproxen and Covera-hs drug interactions.

What are the common drug interactions of Naproxen and Covera-Hs, by gender? *:

female:

  1. Fall
  2. Injury
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  4. Pain in extremity
  5. Pneumonia
  6. Renal failure chronic (long lasting kidney dysfunction)
  7. Acetabulum fracture (socket of the hip joint- fracture)
  8. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  9. Anxiety
  10. Arrhythmia (irregular heartbeat)

male:

  1. Cardiac failure congestive
  2. Cardiovascular disorder (heart diseases)
  3. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  4. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the common drug interactions of Naproxen and Covera-Hs, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Cholecystitis chronic (long lasting infection of gallbladder)
  2. Dysmenorrhoea (painful menstruation)
  3. Dyspepsia (indigestion)
  4. Eating disorder
  5. Headache (pain in head)
  6. Ovarian cyst (fluid filled sac of the ovary)
  7. Thyroid disorder (thyroid diseases)
  8. Type 2 diabetes mellitus
  9. Vomiting
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pallor
  2. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  3. Pneumonia
  4. Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
  5. Post-operative wound infection
  6. Protein total decreased
  7. Pulmonary hypertension (increase in blood pressure in the lung artery)
  8. Renal cell carcinoma stage unspecified (kidney cancer in unknown stage)
  9. Renal failure acute (rapid kidney dysfunction)
  10. Renal failure chronic (long lasting kidney dysfunction)

60+:

  1. Akathisia (a movement disorder characterized by a feeling of inner restlessness)
  2. Blood cholesterol increased
  3. Gastritis (inflammation of stomach)
  4. Haematocrit decreased
  5. Haemoglobin decreased
  6. Injury
  7. Joint effusion (presence of extra fluid in joint covering)
  8. Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
  9. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  10. Mitral valve incompetence (inefficient heart valve)

What are the existing conditions these people have? *

  1. Metastatic Neoplasm (spreadable cancer tumour): 11 people, 50.00%
  2. Hypersensitivity: 11 people, 50.00%
  3. Diabetes: 11 people, 50.00%
  4. Breast Cancer Metastatic: 11 people, 50.00%
  5. Type 2 Diabetes: 3 people, 13.64%
  6. Premenstrual Syndrome: 3 people, 13.64%
  7. Migraine (headache): 3 people, 13.64%
  8. Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 13.64%
  9. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 13.64%
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Naproxen and Covera-hs:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Covera-hs:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naproxen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Covera-hs and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen and verapamil hydrochloride (the active ingredients of Naproxen and Covera-hs, respectively), and Naproxen and Covera-hs (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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