Naproxen and Hydroxocobalamin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Hydroxocobalamin (hydroxocobalamin). Common drug interactions include paraesthesia among females and pain in extremity among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Hydroxocobalamin. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Hydroxocobalamin?

Hydroxocobalamin has active ingredients of hydroxocobalamin. It is often used in pernicious anaemia. eHealthMe is studying from 4,273 Hydroxocobalamin users. Check the latest studies of Hydroxocobalamin.

On Aug, 09, 2026

92 people who take Naproxen and Hydroxocobalamin together, and have interactions are studied.

Naproxen and Hydroxocobalamin drug interactions.

What are the common drug interactions of Naproxen and Hydroxocobalamin, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Diarrhoea
Myalgia (muscle pain)
Sensory disturbance (sense disturbance)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Pruritus (severe itching of the skin)
Drug intolerance (drug sensitivity)

male:

Pain in extremity
Arthralgia (joint pain)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Tremor (trembling or shaking movements in one or more parts of your body)
Cardiac failure
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Agitation (state of anxiety or nervous excitement)
Cough
Depression
Diabetic foot

What are the common drug interactions of Naproxen and Hydroxocobalamin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion induced (medically referred abortion)
Maternal exposure during pregnancy (use of substance during pregnancy)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

30-39:

Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sensory disturbance (sense disturbance)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Pruritus (severe itching of the skin)
Cellulitis (infection under the skin)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Erythema (redness of the skin)
Nasal ulcer (ulcer of nose)

40-49:

Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Chest discomfort
Palpitations (feelings or sensations that your heart is pounding or racing)
Crying
Depression
Headache (pain in head)
Immune system disorder
Nausea (feeling of having an urge to vomit)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

50-59:

Rash
Myalgia (muscle pain)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin reaction
Cardiac failure
Cough
Depressed level of consciousness
Drug effect decreased
Ear pain
Headache (pain in head)

60+:

Pain in extremity
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Loss of proprioception (loss of senses of body and parts)
Myalgia (muscle pain)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Swelling face

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 11.96%
Asthma: 10 people, 10.87%
Nausea (feeling of having an urge to vomit): 8 people, 8.70%
Ill-Defined Disorder: 8 people, 8.70%
Oropharyngeal Pain: 6 people, 6.52%
Lower Respiratory Tract Infection: 6 people, 6.52%
Dyspnea (difficult or laboured breathing): 6 people, 6.52%
Vitamin B12 Deficiency: 5 people, 5.43%
Neck Pain: 5 people, 5.43%
Constipation: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and Hydroxocobalamin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously