Naproxen and Paxil cr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Paxil cr (paroxetine hydrochloride). Common drug interactions include chronic kidney disease among females and breech presentation among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Paxil cr. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Paxil cr?

Paxil cr has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 8,322 Paxil cr users. Check the latest studies of Paxil cr.

On Jul, 13, 2026

61 people who take Naproxen and Paxil cr together, and have interactions are studied.

Naproxen and Paxil cr drug interactions.

What are the common drug interactions of Naproxen and Paxil Cr, by gender? *:

female:

Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries
Depressive symptom
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Disturbance in attention
Dizziness
Drug ineffective
Emotional distress

male:

Breech presentation
Cardiac failure congestive
Pulmonary oedema (fluid accumulation in the lungs)
Pulmonary valve stenosis (heart valve disorder in which outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve)
Respiratory disorder (respiratory disease)
Right ventricle outflow tract obstruction
Vomiting
Weight gain poor
Suicidal ideation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the common drug interactions of Naproxen and Paxil Cr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Bone density decreased
Bone loss
Mobility decreased (ability to move is reduced)
Multiple fractures
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Renal injury (kidney injury)
Skeletal injury (bone and supporting muscle injury)

40-49:

Abdominal pain
Dyspnoea exertional (breathlessness or shortness of breath)
Swelling
Weight increased
Oedema (fluid collection in tissue)
Fluid overload (too much fluid in the blood)
Type 2 diabetes mellitus
Blood cholesterol increased
Blood glucose increased
Blood triglycerides increased

50-59:

Breast cancer stage i
Agitation (state of anxiety or nervous excitement)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Apathy
Asthenia (weakness)
Blood urine present
Chest pain
Completed suicide (act of taking one's own life)
Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Dyspnoea (difficult or laboured respiration)
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Chest discomfort
Chest pain
Dysphagia (a condition in which swallowing is difficult or painful)
Faeces discoloured
Gastritis (inflammation of stomach)
Gingival ulceration (ulcer on gums)
Haematemesis (vomiting of blood)
Haemoglobin decreased

What are the existing conditions these people have? *

Depression: 20 people, 32.79%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 16.39%
Bipolar Disorder (mood disorder): 8 people, 13.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.56%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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