Naproxen and Pemetrexed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Pemetrexed (pemetrexed). Common drug interactions include metastases to central nervous system among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Pemetrexed. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

On Jul, 30, 2026

69 people who take Naproxen and Pemetrexed together, and have interactions are studied.

Naproxen and Pemetrexed drug interactions.

What are the common drug interactions of Naproxen and Pemetrexed, by gender? *:

female:

Metastases to central nervous system (cancer spreads to central nervous system)
Myelosuppression (a decrease in the production of blood cells)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pulmonary alveolar haemorrhage (acute bleeding)
Pulmonary haemorrhage (acute bleeding from the lung)
Rash
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Intestinal perforation (complete penetration of the wall of the intestine)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood fibrinogen increased
Blood glucose increased
Inflammation
Pulmonary haemorrhage (acute bleeding from the lung)
Septic shock (shock due to blood infection)
Constipation

What are the common drug interactions of Naproxen and Pemetrexed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Vomiting

40-49:

Drug ineffective
Inflammation

50-59:

Arthralgia (joint pain)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Pain in extremity
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Drug eruption (adverse drug reaction of the skin)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Vomiting

60+:

Intestinal perforation (complete penetration of the wall of the intestine)
Renal failure acute (rapid kidney dysfunction)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Gamma-glutamyltransferase increased
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 28 people, 40.58%
Constipation: 13 people, 18.84%
Nausea (feeling of having an urge to vomit): 13 people, 18.84%
Non-Small Cell Lung Cancer Stage Iv: 10 people, 14.49%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 10 people, 14.49%
Sedation: 7 people, 10.14%
Fever: 7 people, 10.14%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 7 people, 10.14%
Mucosal Inflammation (infection of mucous membrane): 7 people, 10.14%
Mouth Ulcers: 7 people, 10.14%

* Approximation only. Some reports may have incomplete information.

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