Nolvadex and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nolvadex (tamoxifen citrate) and Wellbutrin (bupropion hydrochloride). Common drug interactions include gait disturbance among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Nolvadex and Wellbutrin. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Nolvadex?

Nolvadex has active ingredients of tamoxifen citrate. It is often used in breast cancer. eHealthMe is studying from 5,506 Nolvadex users. Check the latest studies of Nolvadex.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 15, 2026

46 people who take Nolvadex and Wellbutrin together, and have interactions are studied.

Nolvadex and Wellbutrin drug interactions.

What are the common drug interactions of Nolvadex and Wellbutrin, by gender? *:

female:

Gait disturbance
Hot flush (sudden feelings of heat)
Hypoaesthesia (reduced sense of touch or sensation)
Hypophagia (reduced food intake)
Infection
Pyrexia (fever)
Toothache (tooth pain)
Arthralgia (joint pain)
Weight increased
Neuropathy peripheral (surface nerve damage)

male:

Asthenia (weakness)
Hyperkalaemia (damage to or disease of the kidney)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Nolvadex and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bone callus excessive (excessive bony deposit formed between and around the broken ends of bone fractures)
Bone disorder
Bone fragmentation
Bone pain
Fatigue (feeling of tiredness)
Femur fracture
Injury
Metastases to lymph nodes (cancer spreads to lymph node)
Osteonecrosis of jaw (death of bone of jaw)
Pain in extremity

20-29:

n/a

30-39:

Arthralgia (joint pain)
Back pain
Bone disorder
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cervix carcinoma (cancer of cervix)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Delusion (a false belief or opinion)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Dysarthria (speech disorder)

40-49:

Abdominal distension
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Bone pain
Breast disorder
Breast pain
Cardiac murmur (an heart sound in valve abnormality)
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hirsutism (abnormal growth of hair on a person's face and body, esp. on a woman)

50-59:

Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Accident
Anaemia (lack of blood)
Appetite disorder (abnormal eating habits)
Asthenia (weakness)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Bone disorder
Bone erosion
Bone pain

60+:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Breast cancer recurrent
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cervix carcinoma (cancer of cervix)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Deformity (disfigurement)
Dehydration (dryness resulting from the removal of water)
Delusion (a false belief or opinion)
Dental caries
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

What are the existing conditions these people have? *

Sleep Apnea Syndrome: 14 people, 30.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 26.09%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 9 people, 19.57%
Neuropathy Peripheral (surface nerve damage): 7 people, 15.22%
Metastases To Bone (cancer spreads to bone): 7 people, 15.22%
Bipolar Disorder (mood disorder): 4 people, 8.70%
Bone Density Decreased: 4 people, 8.70%
Bone Loss: 4 people, 8.70%
Hot Flush (sudden feelings of heat): 3 people, 6.52%
Back Pain: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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