Norflex and Norvasc drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Norvasc (amlodipine besylate). Common drug interactions include nausea among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Norvasc. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Norvasc?

Norvasc has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 136,738 Norvasc users. Check the latest studies of Norvasc.

On Jul, 07, 2026

66 people who take Norflex and Norvasc together, and have interactions are studied.

What are the common drug interactions of Norflex and Norvasc, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pain
Pneumonia
Syncope (loss of consciousness with an inability to maintain postural tone)
Headache (pain in head)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anxiety
Dyslipidaemia (abnormal amount of lipids)
Emotional distress
Headache (pain in head)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Obesity (having too much body fat)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Norflex and Norvasc, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cystitis (inflammation of the wall of the bladder)
Lipase increased
Small intestinal obstruction (blockage in small intestine)
Dysaesthesia (abnormal sensation)
Facial pain
Headache (pain in head)
Hemiplegia (paralysis of one side of the body)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

30-39:

n/a

40-49:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Anoxic encephalopathy (brain damage due to lack of oxygen)
Anxiety
Apnoea (suspension of external breathing)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dyslipidaemia (abnormal amount of lipids)
Emotional distress
Headache (pain in head)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Oedema peripheral (superficial swelling)
Pneumonia
Syncope (loss of consciousness with an inability to maintain postural tone)
Cardiac disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delirium (wild excitement)
Dyspepsia (indigestion)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Glaucoma (increased fluid pressure in the eye with vision loss)

60+:

Drug hypersensitivity
Asthenia (weakness)
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Diarrhoea
Facial palsy (paralysis of face nerve)
Fall
Fatigue (feeling of tiredness)
Fear

What are the existing conditions these people have? *

Pain: 10 people, 15.15%
Depression: 10 people, 15.15%
Sleep Disorder: 7 people, 10.61%
Back Pain: 7 people, 10.61%
Stable Angina (a constant chest pain): 6 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.58%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 7.58%
Hypersensitivity: 5 people, 7.58%
Diabetes: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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