Norflex and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Zoloft (sertraline hydrochloride). Common drug interactions include fatigue among females and hyperglycaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Zoloft. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 07, 2026

86 people who take Norflex and Zoloft together, and have interactions are studied.

What are the common drug interactions of Norflex and Zoloft, by gender? *:

female:

Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Myalgia (muscle pain)
Dizziness
Sinusitis (inflammation of sinus)
Ear pain
Alopecia (absence of hair from areas of the body)
Myositis (inflammation of the muscles)
Confusional state
Deafness

male:

Hyperglycaemia (high blood sugar)
Intervertebral disc protrusion (spinal disc protrusion)
Suicidal ideation
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Back disorder
Cervical vertebral fracture
Impaired fasting glucose
Lumbar radiculopathy (radicular pain in the low back and legs)
Type 2 diabetes mellitus
Acute myocardial infarction (acute heart attack)

What are the common drug interactions of Norflex and Zoloft, by age (0-1 to 60+)? *:

0-1:

Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)

2-9:

n/a

10-19:

n/a

20-29:

Suicide attempt
Acute sinusitis
Attention deficit/hyperactivity disorder
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Hypertension (high blood pressure)
Injury
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)

30-39:

Drug addiction
Back disorder
Cervical vertebral fracture
Hyperglycaemia (high blood sugar)
Impaired fasting glucose
Intervertebral disc protrusion (spinal disc protrusion)
Lumbar radiculopathy (radicular pain in the low back and legs)
Type 2 diabetes mellitus
Weight increased
Anaemia (lack of blood)

40-49:

Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Asthenia (weakness)
Pain
Arthralgia (joint pain)
Ear pain
Pain in extremity
Alopecia (absence of hair from areas of the body)
Fall

50-59:

Pulmonary function test nos decreased
Pyelonephritis (inflammation of kidney caused by bacteria)
Pyrexia (fever)
Rectal bleeding (bleeding from rectum)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Skin ulcer
Upper respiratory tract infection
Urinary tract infection
Vaginitis bacterial (inflammation of the vagina caused by bacterial infection)
Vomiting

60+:

Pain
Red man syndrome (a reaction to the drug vancomycin)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysphasia (language disorder marked by deficiency in the generation of speech)
Dysstasia (difficulty in standing)
Fear
Hemiplegia (paralysis of one side of the body)
Injection site reaction
Injury
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)

What are the existing conditions these people have? *

Hepatitis C: 15 people, 17.44%
Menopause (end of monthly cycles in women): 7 people, 8.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 8.14%
Pain: 6 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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