Oracea and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oracea (doxycycline) and Spironolactone (spironolactone). Common drug interactions include migraine among females.

The phase IV clinical study analyzes what interactions people have when they take Oracea and Spironolactone. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Oracea?

Oracea has active ingredients of doxycycline. It is often used in rosacea. eHealthMe is studying from 1,272 Oracea users. Check the latest studies of Oracea.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 07, 2026

44 people who take Oracea and Spironolactone together, and have interactions are studied.

Oracea and Spironolactone drug interactions.

What are the common drug interactions of Oracea and Spironolactone, by gender? *:

female:

Migraine (headache)
Pain
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Appendicitis (inflammation of the appendix)
Blood sodium decreased
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chronic kidney disease
Headache (pain in head)

male:

n/a

What are the common drug interactions of Oracea and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injection site erythema (redness at injection site)
Injection site pain
Injection site warmth
Rash

30-39:

Drug ineffective
Pain
Stress
Suicidal ideation
Erythema (redness of the skin)
Skin swelling

40-49:

Cataract (clouding of the lens inside the eye)

50-59:

Renal failure (kidney dysfunction)
Tenderness (pain or discomfort when an affected area is touched)
Erythema (redness of the skin)
Oropharyngeal pain
Renal impairment (severely reduced kidney function)
Sinusitis (inflammation of sinus)
Swelling face
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hepatic enzyme increased
Anxiety

60+:

Chest discomfort
Cough
Lip swelling
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

What are the existing conditions these people have? *

Drowsiness: 14 people, 31.82%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 18.18%
High Blood Pressure: 7 people, 15.91%
High Blood Cholesterol: 5 people, 11.36%
Hypersensitivity: 4 people, 9.09%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 3 people, 6.82%
Immunodeficiency Common Variable: 3 people, 6.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

Do you take Oracea and Spironolactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously