Orfadin and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orfadin (nitisinone) and Acetaminophen (acetaminophen). Common drug interactions include amino acid level increased among females and amino acid level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Orfadin and Acetaminophen. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Orfadin?

Orfadin has active ingredients of nitisinone. eHealthMe is studying from 968 Orfadin users. Check the latest studies of Orfadin.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 16, 2026

15 people who take Orfadin and Acetaminophen together, and have interactions are studied.

Orfadin and Acetaminophen drug interactions.

What are the common drug interactions of Orfadin and Acetaminophen, by gender? *:

female:

Amino acid level increased
Cataract (clouding of the lens inside the eye)
Lenticular opacities (swelling and opacity of the entire lens)
Conjunctival oedema (conjunctival swelling)
Conjunctival pigmentation (colour of conctiva)
Conjunctivitis (pink eye)
Scleral disorder (disease of sclera)

male:

Amino acid level increased
Cataract (clouding of the lens inside the eye)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatic neoplasm malignant (liver cancer)
Immunosuppressant drug level increased
Liver disorder (liver diseases)
Liver transplant
Nasal disorder (diseases of nose)
Lenticular opacities (swelling and opacity of the entire lens)
Conjunctivitis (pink eye)

What are the common drug interactions of Orfadin and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation postoperative
Alpha 1 foetoprotein increased
Confusion postoperative
Drug ineffective
Hallucination, visual (seeing things that aren't there)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatic neoplasm malignant (liver cancer)
Immunosuppressant drug level increased
Liver disorder (liver diseases)
Liver transplant

20-29:

n/a

30-39:

n/a

40-49:

Lenticular opacities (swelling and opacity of the entire lens)
Conjunctival oedema (conjunctival swelling)
Conjunctival pigmentation (colour of conctiva)
Conjunctivitis (pink eye)
Nasal disorder (diseases of nose)
Scleral disorder (disease of sclera)
Amino acid level increased
Cataract (clouding of the lens inside the eye)

50-59:

Amino acid level increased
Cataract (clouding of the lens inside the eye)
Lenticular opacities (swelling and opacity of the entire lens)
Conjunctivitis (pink eye)

60+:

Amino acid level increased
Cataract (clouding of the lens inside the eye)
Lenticular opacities (swelling and opacity of the entire lens)
Conjunctival oedema (conjunctival swelling)

What are the existing conditions these people have? *

Alkaptonuria (black urine disease): 14 people, 93.33%
Tyrosinaemia (tyrosine metabolism resulting in liver and kidney disturbances and mental retardation): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Orfadin and Acetaminophen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously