Otezla and Otrexup drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Otrexup (methotrexate). Common drug interactions include pain among females and rheumatoid arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Otrexup. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

On Jul, 07, 2026

32 people who take Otezla and Otrexup together, and have interactions are studied.

What are the common drug interactions of Otezla and Otrexup, by gender? *:

female:

Pain
Vomiting
Hepatitis c
Swelling
Depression
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Pain in extremity
Surgery
Fibromyalgia (a long-term condition which causes pain all over the body)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Drug ineffective
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Depression
Insomnia (sleeplessness)
Lower respiratory tract infection
Sinusitis (inflammation of sinus)

What are the common drug interactions of Otezla and Otrexup, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Psoriasis (immune-mediated disease that affects the skin)

30-39:

n/a

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Memory impairment

50-59:

Diarrhoea
Drug ineffective
Eye haemorrhage (bleeding in the eye)
Headache (pain in head)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Weight decreased
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Stress

60+:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Depression
Drug ineffective
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Lower respiratory tract infection
Sinusitis (inflammation of sinus)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 19 people, 59.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 15.62%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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