Otrexup and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otrexup (methotrexate) and Ibuprofen (ibuprofen). Common drug interactions include drug effect decreased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Otrexup and Ibuprofen. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 27, 2026

18 people who take Otrexup and Ibuprofen together, and have interactions are studied.

Otrexup and Ibuprofen drug interactions.

What are the common drug interactions of Otrexup and Ibuprofen, by gender? *:

female:

Drug effect decreased
Drug hypersensitivity
Eye disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hidradenitis (chronic disease of a type of sweat gland)
Knee arthroplasty
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Spinal stenosis (narrowing of spinal column)

male:

Diarrhoea
Cough
Influenza
Pyrexia (fever)

What are the common drug interactions of Otrexup and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Infection

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Drug hypersensitivity
Knee arthroplasty
Nausea (feeling of having an urge to vomit)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Drug ineffective
Adverse event
Diarrhoea

60+:

Cough
Eye disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Influenza
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pyrexia (fever)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 33.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 22.22%
Hidradenitis (chronic disease of a type of sweat gland): 2 people, 11.11%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%
Morphea: 1 person, 5.56%
Migraine (headache): 1 person, 5.56%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.56%
Arthropathy: 1 person, 5.56%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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