Percodan and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate) and Acetaminophen (acetaminophen). Common drug interactions include vomiting among females and malignant pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Percodan and Acetaminophen. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 12, 2026

22 people who take Percodan and Acetaminophen together, and have interactions are studied.

Percodan and Acetaminophen drug interactions.

What are the common drug interactions of Percodan and Acetaminophen, by gender? *:

female:

Vomiting
Constipation
Overdose
Hyporeflexia (a condition of below normal or absent reflexes)
Intestinal obstruction
Abdominal pain
Drug hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oesophageal disorder (disease of oesophagus)

male:

Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Pleural effusion (water on the lungs)
Hepatic congestion (liver congestion)
Needle track marks
Nephropathy (damage to or disease of a kidney)
Pulmonary congestion (congestion in the lungs)
Splenomegaly (enlargement of spleen)
Urine analysis abnormal
Drug dependence
Polyarthritis (arthritis which involves 5 or more joints simultaneously)

What are the common drug interactions of Percodan and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Drug dependence
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Hepatic congestion (liver congestion)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

40-49:

Drug dependence

50-59:

Polyarthritis (arthritis which involves 5 or more joints simultaneously)

60+:

Constipation
Overdose
Paralysed
Reflexes abnormal (body receives a certain stimulus not normally)
Vomiting
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Pleural effusion (water on the lungs)
Hyporeflexia (a condition of below normal or absent reflexes)
Intestinal obstruction
Completed suicide (act of taking one's own life)

What are the existing conditions these people have? *

Prostate Cancer Metastatic: 7 people, 31.82%
Metastases To Bone (cancer spreads to bone): 7 people, 31.82%
Joint Pain: 7 people, 31.82%
High Blood Pressure: 7 people, 31.82%
High Blood Cholesterol: 7 people, 31.82%
Diabetes: 7 people, 31.82%
Cardiac Disorder: 7 people, 31.82%
Cancer Pain: 7 people, 31.82%

* Approximation only. Some reports may have incomplete information.

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