Premphase and Fosamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate) and Fosamax (alendronate sodium). Common drug interactions include femur fracture among females.

The phase IV clinical study analyzes what interactions people have when they take Premphase and Fosamax. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

On Jul, 16, 2026

33 people who take Premphase and Fosamax together, and have interactions are studied.

Premphase and Fosamax drug interactions.

What are the common drug interactions of Premphase and Fosamax, by gender? *:

female:

Femur fracture
Bone disorder
Breast cancer
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pain in extremity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Abdominal discomfort
Breast cancer female
Groin pain
Hip deformity

male:

n/a

What are the common drug interactions of Premphase and Fosamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

50-59:

Staphylococcal bacteraemia (a bacterial infection of blood)
Streptococcal sepsis (whole body inflammation by streptococcal)
Systemic candida (whole body fungal infection)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Weaning failure
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Anxiety
Depression

60+:

Abdominal discomfort
Arthralgia (joint pain)
Procedural pain
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Breast cancer female
Bacteraemia (presence of bacteria in the blood)
Cellulitis (infection under the skin)
Joint dislocation (a joint position is changed from normal position)
Osteomyelitis chronic (long lasting infection of bone marrow)
Osteonecrosis (death of bone)

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 21.21%
Menopause (end of monthly cycles in women): 2 people, 6.06%
High Blood Pressure: 2 people, 6.06%
Bone Density Decreased: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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