Profen and Cotellic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Cotellic (cobimetinib fumarate). Common drug interactions include rash among females and haemorrhage urinary tract among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Cotellic. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Cotellic?

Cotellic has active ingredients of cobimetinib fumarate. eHealthMe is studying from 1,908 Cotellic users. Check the latest studies of Cotellic.

On Jul, 07, 2026

18 people who take Profen and Cotellic together, and have interactions are studied.

What are the common drug interactions of Profen and Cotellic, by gender? *:

female:

Rash
Acne (skin problems that cause pimples)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Conjunctivitis (pink eye)
Eye swelling
Lip swelling
Onychoclasis (breaking of the nails)

male:

Haemorrhage urinary tract (bleeding from uterine)
Abasia (inability to walk)
Anger
Angioedema (rapid swelling of the dermis)
Cardiac disorder
Rash generalised (rash on most of body parts)
Swelling face

What are the common drug interactions of Profen and Cotellic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Angioedema (rapid swelling of the dermis)
Swelling face

50-59:

Abasia (inability to walk)
Abdominal pain
Anger
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Blood creatine phosphokinase increased
Cardiac disorder
Decreased appetite
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

60+:

Diarrhoea
Rash
Nausea (feeling of having an urge to vomit)
Onychoclasis (breaking of the nails)
Oral candidiasis (fungal infection of mouth)
Peripheral swelling
Pneumonia
Pyrexia (fever)
Swollen tongue (swelling of tongue)
Dry mouth

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 8 people, 44.44%
Metastases To Lymph Nodes (cancer spreads to lymph node): 7 people, 38.89%
Abscess (pus): 7 people, 38.89%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 6 people, 33.33%
Ovarian Cancer (cancer of ovary): 3 people, 16.67%
Vitamin B12 Deficiency: 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Fever: 2 people, 11.11%
Skin Cancer: 1 person, 5.56%
Abdominal Pain Upper: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Cotellic?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously