Prometrium and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Glucophage (metformin hydrochloride). Common drug interactions include pain in extremity among females and ectopic kidney among males.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Glucophage. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 21, 2026

53 people who take Prometrium and Glucophage together, and have interactions are studied.

Prometrium and Glucophage drug interactions.

What are the common drug interactions of Prometrium and Glucophage, by gender? *:

female:

Pain in extremity
Abdominal pain
Arthralgia (joint pain)
Depression
Dizziness
Insomnia (sleeplessness)
Oedema peripheral (superficial swelling)
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight increased
Anaemia (lack of blood)

male:

Ectopic kidney (kidney that is not located in its usual position)
Feeding disorder (when children refuse to eat certain food groups)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Maternal exposure during pregnancy (use of substance during pregnancy)
Premature baby
Speech disorder

What are the common drug interactions of Prometrium and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bone pain
Depression
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Neck pain
Road traffic accident
Weight decreased
Weight increased

30-39:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Arthralgia (joint pain)
Blood iron decreased
Blood pressure fluctuation
Contusion (a type of hematoma of tissue in which capillaries)
Deformity (disfigurement)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dizziness
Fallopian tube disorder (fallopian tube disease)
Fatigue (feeling of tiredness)

40-49:

Drug ineffective
Abdominal pain
Akinesia (loss of control of voluntary muscle movements)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Cardiac arrest
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Confusion

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Emotional disorder
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Faeces pale
Fatigue (feeling of tiredness)
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Flatulence (flatus expelled through the anus)
Gait abnormal

60+:

Headache (pain in head)
Abdominal pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Injury
Leukopenia (less number of white blood cells in blood)
Liver disorder (liver diseases)
Metastases to lymph nodes (cancer spreads to lymph node)

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 24.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 13.21%
Malaria (a parasitic disease due to mosquito bite): 6 people, 11.32%
Type 2 Diabetes: 3 people, 5.66%
Neck Pain: 3 people, 5.66%
Bladder Disorder: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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