Restoril and Depo-provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Restoril (temazepam) and Depo-provera (medroxyprogesterone acetate). Common drug interactions include stress among females.

The phase IV clinical study analyzes what interactions people have when they take Restoril and Depo-provera. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.



On Jul, 17, 2026

19 people who take Restoril and Depo-provera together, and have interactions are studied.

Restoril and Depo-provera drug interactions.

What are the common drug interactions of Restoril and Depo-Provera, by gender? *:

female:

  1. Stress
  2. Arthralgia (joint pain)
  3. Arthropathy
  4. Back pain
  5. Blood calcium decreased
  6. Clavicle fracture
  7. Contusion (a type of hematoma of tissue in which capillaries)
  8. Gait disturbance
  9. Injection site pain
  10. Intervertebral disc degeneration (spinal disc degeneration)

male:

n/a

What are the common drug interactions of Restoril and Depo-Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Injection site haemorrhage (bleeding from injection site)
  2. Migraine (headache)
  3. Pneumonia
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Tooth disorder (tooth disease)
  6. Blood creatine phosphokinase increased
  7. Fall
  8. Hepatotoxicity (chemical-driven liver damage)
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Impaired healing

40-49:

  1. Arthralgia (joint pain)
  2. Pain
  3. Gait disturbance
  4. Injection site pain
  5. Intervertebral disc degeneration (spinal disc degeneration)
  6. Lethargy (tiredness)
  7. Petit mal epilepsy (absence seizure)
  8. Stress
  9. Upper limb fracture
  10. Vitamin d decreased

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 5 people, 26.32%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 26.32%
  3. Pain: 4 people, 21.05%
  4. Osteoporosis (bones weak and more likely to break): 4 people, 21.05%
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 21.05%
  6. Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 15.79%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.53%
  8. Stress And Anxiety: 1 person, 5.26%
  9. Neuralgia (pain in one or more nerves): 1 person, 5.26%
  10. Nausea And Vomiting: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Restoril and Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Restoril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Restoril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Depo-provera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on temazepam and medroxyprogesterone acetate (the active ingredients of Restoril and Depo-provera, respectively), and Restoril and Depo-provera (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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