Ritalin and Cyclophosphamide drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Cyclophosphamide (cyclophosphamide). Common drug interactions include nausea among females and encephalopathy among males.
The phase IV clinical study analyzes what interactions people have when they take Ritalin and Cyclophosphamide. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.
What is Ritalin?
Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.
What is Cyclophosphamide?
Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.
48 people who take Ritalin and Cyclophosphamide together, and have interactions are studied.

What are the common drug interactions of Ritalin and Cyclophosphamide, by gender? *:
female:
- Nausea (feeling of having an urge to vomit)
- Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
- Gastrointestinal ulcer
- Urinary tract infection
- Febrile neutropenia (fever with reduced white blood cells)
- Neutropenia (an abnormally low number of neutrophils)
- Rectal fissure (painful condition in which a cut or tear occurs in the anus)
- Anxiety
- Breast cancer
- Hospitalisation
male:
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Dyspnoea (difficult or laboured respiration)
- Thermal burn (burn by heat)
- Aphonia (inability to produce voice)
- Escherichia urinary tract infection (urinary tract infection by escherichia coli)
- Optic neuropathy (optic nerve damage)
- Oxygen saturation decreased
- Radiation retinopathy (eye damage due to radiation)
- Staphylococcal abscess (pus formation due to staphylococcal bacteria)
- Aseptic necrosis bone
What are the common drug interactions of Ritalin and Cyclophosphamide, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Cardiac failure
- Cardiac failure acute
30-39:
- Febrile neutropenia (fever with reduced white blood cells)
- Nausea (feeling of having an urge to vomit)
- Neutropenia (an abnormally low number of neutrophils)
- Rectal fissure (painful condition in which a cut or tear occurs in the anus)
- Breast cancer metastatic
- Cellulitis (infection under the skin)
- Diarrhoea
- Proctalgia (pain in the rectum)
- Pulmonary embolism (blockage of the main artery of the lung)
- Rectal abscess (pus in rectum)
40-49:
n/a
50-59:
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Anxiety
- Breast cancer
- Cardiac arrest
- Hospitalisation
- Hypokalaemia (low potassium)
- Muscle spasms (muscle contraction)
- Nausea (feeling of having an urge to vomit)
- Panic attack
- Pneumonia
60+:
- B-cell type acute leukaemia (cancer of the white blood cells)
- Fatigue (feeling of tiredness)
- Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
- Rib fracture
- Haematocrit decreased
- Haemoglobin decreased
- Lymphocyte count decreased
- Red blood cell count decreased
- Red cell distribution width increased
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 33.33%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 31.25%
- Bone Marrow Conditioning Regimen: 5 people, 10.42%
- Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 8.33%
- Breast Cancer: 4 people, 8.33%
- Ovarian Cancer (cancer of ovary): 3 people, 6.25%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.25%
- Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 3 people, 6.25%
* Approximation only. Some reports may have incomplete information.
Do you take Ritalin and Cyclophosphamide?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Ritalin (29,427 reports)
- Cyclophosphamide (185,240 reports)
Browse all drug interactions of Ritalin and Cyclophosphamide:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Ritalin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cyclophosphamide:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Ritalin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cyclophosphamide and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on methylphenidate hydrochloride and cyclophosphamide (the active ingredients of Ritalin and Cyclophosphamide, respectively), and Ritalin and Cyclophosphamide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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