Robinul and Seroquel drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Robinul (glycopyrrolate) and Seroquel (quetiapine fumarate). Common drug interactions include purpura among females and drug ineffective among males.
The phase IV clinical study analyzes what interactions people have when they take Robinul and Seroquel. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.
What is Robinul?
Robinul has active ingredients of glycopyrrolate. It is often used in hyperhidrosis. eHealthMe is studying from 1,663 Robinul users. Check the latest studies of Robinul.
What is Seroquel?
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.
51 people who take Robinul and Seroquel together, and have interactions are studied.

What are the common drug interactions of Robinul and Seroquel, by gender? *:
female:
- Purpura (purplish discoloration of the skin)
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
- Synovitis (inflammation of the synovial membrane)
- Unresponsive to stimuli
- Agitation (state of anxiety or nervous excitement)
- Anxiety disorder
- Appetite disorder (abnormal eating habits)
- Ascites (accumulation of fluid in the abdominal cavity)
- Bile duct stone
- Hypertension (high blood pressure)
male:
- Drug ineffective
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Death
- Delusion (a false belief or opinion)
- Hypotension (abnormally low blood pressure)
- Ill-defined disorder
- Loss of consciousness
- Multiple injuries
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Pain in extremity
What are the common drug interactions of Robinul and Seroquel, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Adverse event
10-19:
- Abnormal behaviour
- Aggression
20-29:
- Obesity (having too much body fat)
- Type 2 diabetes mellitus
30-39:
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Gallbladder disorder
- Chronic kidney disease
- Drug ineffective
- Nephrogenic anaemia (anaemia due to kidney disease)
- Renal failure (kidney dysfunction)
- Restless legs syndrome (a powerful urge to move your legs)
- Sleep disorder
- Therapeutic response unexpected
- Fungal infection
40-49:
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Atrophic vulvovaginitis (inflammation of the vulva)
- Carotid artery disease
- Carotid artery occlusion (artery blockage)
- Cough
- Deafness
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
- Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
- Dizziness
50-59:
- Back pain
- Chest pain
- Neck pain
- Abdominal distension
- Abdominal pain
- Abdominal pain upper
- Adrenal mass
- Agitation (state of anxiety or nervous excitement)
- Deafness unilateral
- Dementia (madness)
60+:
- Hypocalcaemia (levels of calcium in blood serum are abnormally low)
- Blood creatinine increased
- Tetany (involuntary contraction of muscles)
- Death
- Delusion (a false belief or opinion)
- Hypotension (abnormally low blood pressure)
- Loss of consciousness
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Pain in extremity
- Adverse event
What are the existing conditions these people have? *
- Depression: 13 people, 25.49%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 25.49%
- High Blood Pressure: 12 people, 23.53%
- Anaemia (lack of blood): 10 people, 19.61%
- Indigestion: 10 people, 19.61%
- Incontinence (lack of moderation or self-control): 9 people, 17.65%
- Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 9 people, 17.65%
- Joint Pain: 9 people, 17.65%
- Laryngitis (inflammation of the larynx): 9 people, 17.65%
- Cough: 9 people, 17.65%
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Robinul and Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Robinul:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Robinul and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Seroquel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- D'souza S, Gowler V, "Glycopyrrolate‐induced respiratory arrest: an unusual side effect", Acta Anaesthesiologica Scandinavica, 2015 Mar .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- D'souza S, Gowler V, "Glycopyrrolate‐induced respiratory arrest: an unusual side effect", Acta Anaesthesiologica Scandinavica, 2015 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on glycopyrrolate and quetiapine fumarate (the active ingredients of Robinul and Seroquel, respectively), and Robinul and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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