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Rufinamide and Afinitor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rufinamide (rufinamide) and Afinitor (everolimus). Common drug interactions include convulsion among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Rufinamide and Afinitor. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Rufinamide?

Rufinamide has active ingredients of rufinamide. eHealthMe is studying from 946 Rufinamide users. Check the latest studies of Rufinamide.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

On Jul, 20, 2026

20 people who take Rufinamide and Afinitor together, and have interactions are studied.

Rufinamide and Afinitor drug interactions.

What are the common drug interactions of Rufinamide and Afinitor, by gender? *:

female:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Diarrhoea
  3. Abdominal discomfort
  4. Blood cholesterol increased
  5. Blood creatinine increased
  6. Constipation
  7. Drug intolerance (drug sensitivity)
  8. Electrolyte depletion (act of decreasing electrolyte markedly)
  9. Feeling cold
  10. Muscle spasms (muscle contraction)

male:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Furuncle (infection of the hair follicle)
  3. Drug level decreased
  4. Lipids increased (excess lipid in body)
  5. Oedema peripheral (superficial swelling)

What are the common drug interactions of Rufinamide and Afinitor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it)
  2. Clonic convulsion (long lasting seizure)
  3. Drug level below therapeutic
  4. Fatigue (feeling of tiredness)
  5. Drug level decreased
  6. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

20-29:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Abdominal discomfort
  3. Blood cholesterol increased
  4. Blood creatinine increased
  5. Constipation
  6. Diarrhoea
  7. Drug intolerance (drug sensitivity)
  8. Drug level below therapeutic
  9. Electrolyte depletion (act of decreasing electrolyte markedly)
  10. Feeling cold

30-39:

  1. Atonic seizures (minor type of seizure)
  2. Brain mass
  3. Nausea (feeling of having an urge to vomit)
  4. Rash
  5. Pineal gland cyst
  6. Drug level below therapeutic
  7. Rash erythematous (redness of the skin)
  8. Seasonal allergy (allergic condition due to certain season)

40-49:

  1. Abdominal discomfort
  2. Blood cholesterol increased
  3. Blood triglycerides increased
  4. Diarrhoea
  5. Eating disorder
  6. Neoplasm (tumour)
  7. Stomatitis (inflammation of mucous membrane of mouth)
  8. Weight decreased

50-59:

  1. Oedema peripheral (superficial swelling)
  2. Drug level decreased
  3. Lipids increased (excess lipid in body)

60+:

  1. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  2. Concomitant disease progression (progress in accompanying disease)
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Drug level decreased
  5. Ear infection
  6. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  7. Pneumonia
  8. Weight increased

What are the existing conditions these people have? *

  1. Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 16 people, 80.00%
  2. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.00%
  3. Renal Cell Carcinoma (a kidney cancer): 1 person, 5.00%
  4. Ovarian Epithelial Cancer (cancer that begins in the cells on the surface of the ovary): 1 person, 5.00%
  5. High Blood Pressure: 1 person, 5.00%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.00%
  7. Brain Neoplasm Benign (non-cancerous tumour of brain): 1 person, 5.00%
  8. Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Rufinamide and Afinitor?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rufinamide and Afinitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rufinamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Afinitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rufinamide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Afinitor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rufinamide and everolimus (the active ingredients of Rufinamide and Afinitor, respectively), and Rufinamide and Afinitor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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