Salonpas and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Salonpas (menthol; methyl salicylate) and Ibuprofen (ibuprofen). Common drug interactions include arthralgia among females and application site erythema among males.

The phase IV clinical study analyzes what interactions people have when they take Salonpas and Ibuprofen. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Salonpas?

Salonpas has active ingredients of menthol; methyl salicylate. eHealthMe is studying from 630 Salonpas users. Check the latest studies of Salonpas.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

42 people who take Salonpas and Ibuprofen together, and have interactions are studied.

Salonpas and Ibuprofen drug interactions.

What are the common drug interactions of Salonpas and Ibuprofen, by gender? *:

female:

Arthralgia (joint pain)
Depression
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Malaise (a feeling of general discomfort or uneasiness)
Abdominal distension
Abdominal pain upper
Anxiety
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)

male:

Application site erythema (redness of the skin at application site)
Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface)
Application site irritation
Application site pain
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Nasopharyngitis (inflammation of the nasopharynx)
Skin wrinkling (wrinkle on skin)

What are the common drug interactions of Salonpas and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Weight decreased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Dyskinesia (abnormality or impairment of voluntary movement)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Abdominal pain
Abdominal rigidity
Affective disorder (mental disorder)
Anxiety

40-49:

Abdominal distension
Abdominal pain upper
Oedema peripheral (superficial swelling)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Drug ineffective
Irritable bowel syndrome
Application site burn
Depression
General physical health deterioration (weak health status)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Hypersensitivity
Nasopharyngitis (inflammation of the nasopharynx)
Asthma
Cerebral disorder (brain disease)
Drug ineffective
Overdose
Respiratory depression (respiration has a rate below 12 breaths)

60+:

Joint swelling
Peripheral swelling
Overweight
Anxiety
Aphasia (damage to the parts of the brain that control language)
Application site erythema (redness of the skin at application site)
Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface)
Application site irritation
Application site pain
Carotid artery occlusion (artery blockage)

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 14.29%
Joint Pain: 5 people, 11.90%
Stress And Anxiety: 4 people, 9.52%
Neuralgia (pain in one or more nerves): 4 people, 9.52%
Hypersensitivity: 4 people, 9.52%
Depression: 4 people, 9.52%
Asthma: 4 people, 9.52%
Quit Smoking: 3 people, 7.14%
Muscle Aches (muscle pain): 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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