Serzone and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Naproxen (naproxen). Common drug interactions include fatigue among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Naproxen. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 13, 2026

60 people who take Serzone and Naproxen together, and have interactions are studied.

What are the common drug interactions of Serzone and Naproxen, by gender? *:

female:

Fatigue (feeling of tiredness)
Blood cholesterol increased
Chest discomfort
Chronic kidney disease
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypertension (high blood pressure)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Abdominal pain upper

male:

Abdominal pain
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Weight decreased
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Flatulence (flatus expelled through the anus)
Hepatotoxicity (chemical-driven liver damage)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Sweating increased (excess sweating)

What are the common drug interactions of Serzone and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Petechiae (a small red or purple spot caused by bleeding into the skin)
Platelet count decreased

30-39:

Cataract (clouding of the lens inside the eye)

40-49:

Abdominal pain
Chest pain
Insomnia (sleeplessness)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Pruritus (severe itching of the skin)
Dry mouth
Hepatitis (inflammation of the liver)
Nausea (feeling of having an urge to vomit)
Weight decreased
Confusional state

50-59:

Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Diabetes mellitus non-insulin-dependent
Diarrhoea
Dizziness
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis c
Nephrogenic anaemia (anaemia due to kidney disease)
Thinking abnormal
Chronic kidney disease

60+:

Dizziness
Type 2 diabetes mellitus
Abdominal pain upper
Activities of daily living impaired
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal mass
Anastomotic stenosis
Anastomotic ulcer
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Areflexia (absence of a reflex)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.00%
Bipolar Disorder (mood disorder): 5 people, 8.33%
Stress And Anxiety: 4 people, 6.67%
High Blood Cholesterol: 4 people, 6.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 6.67%
Post-Traumatic Stress Disorder: 3 people, 5.00%
Nausea (feeling of having an urge to vomit): 3 people, 5.00%
Muscle Aches (muscle pain): 3 people, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.00%
High Blood Pressure: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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