Silybum and Calcium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Silybum (milk thistle) and Calcium (calcium). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Silybum and Calcium. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Silybum?

Silybum has active ingredients of milk thistle. eHealthMe is studying from 779 Silybum users. Check the latest studies of Silybum.

What is Calcium?

Calcium has active ingredients of calcium. It is often used in osteoporosis. eHealthMe is studying from 184,201 Calcium users. Check the latest studies of Calcium.

On Jul, 13, 2026

60 people who take Silybum and Calcium together, and have interactions are studied.

What are the common drug interactions of Silybum and Calcium, by gender? *:

female:

Fatigue (feeling of tiredness)
Contusion (a type of hematoma of tissue in which capillaries)
Headache (pain in head)
Pruritus (severe itching of the skin)
Alopecia (absence of hair from areas of the body)
Diarrhoea
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Rash
Weight increased

male:

Fatigue (feeling of tiredness)
Abdominal discomfort
Pain
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Spinal column injury (spinal cord bone injury)
Weight decreased
Death
Decreased appetite
Fall
Flatulence (flatus expelled through the anus)

What are the common drug interactions of Silybum and Calcium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Malaise (a feeling of general discomfort or uneasiness)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash

40-49:

Cellulitis (infection under the skin)
Hypersensitivity
Oedema peripheral (superficial swelling)

50-59:

Peripheral swelling
Pruritus (severe itching of the skin)
Rash
Rash papular (redness with papule)
Skin haemorrhage (bleeding into skin)
Stress
Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred
Vitamin d decreased
Weight increased

60+:

Fatigue (feeling of tiredness)
Contusion (a type of hematoma of tissue in which capillaries)
Aphthous ulcer (mouth ulcer)
Death
Gingival bleeding (bleeding gums)
Hepatic enzyme increased
Herpes zoster
Injury
Limb injury
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 15.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 7 people, 11.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.67%
High Blood Pressure: 4 people, 6.67%
Diarrhea: 4 people, 6.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 5.00%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 5.00%
Itching: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Silybum and Calcium?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously