Simvastatin and Edurant drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Edurant (rilpivirine hydrochloride). Common drug interactions include emotional distress among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Edurant. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Edurant?

Edurant has active ingredients of rilpivirine hydrochloride. eHealthMe is studying from 2,238 Edurant users. Check the latest studies of Edurant.

On Jul, 22, 2026

16 people who take Simvastatin and Edurant together, and have interactions are studied.

Simvastatin and Edurant drug interactions.

What are the common drug interactions of Simvastatin and Edurant, by gender? *:

female:

Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Anaemia (lack of blood)
Arthralgia (joint pain)
Bone density decreased
Depression

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Proteinuria (presence of protein in the urine)
Quality of life decreased
Renal injury (kidney injury)
Upper limb fracture
Dysgeusia (disorder of the sense of taste)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Spinal compression fracture (fracture due to spinal compression on bone)

What are the common drug interactions of Simvastatin and Edurant, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Spinal compression fracture (fracture due to spinal compression on bone)
Upper limb fracture

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

60+:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anxiety
Blood creatinine increased
Emotional distress
Pain
Proteinuria (presence of protein in the urine)
Dysgeusia (disorder of the sense of taste)

What are the existing conditions these people have? *

Hiv Infection: 12 people, 75.00%
Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 25.00%
Interstitial Lung Disease: 3 people, 18.75%
High Blood Pressure: 3 people, 18.75%
Pain: 2 people, 12.50%
Prostatic Disorder: 1 person, 6.25%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 1 person, 6.25%
Microscopic Polyangiitis (inflammation involving multiple blood or lymph small-vessel): 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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